Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect

Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect

Aurora-A kinase is frequently over-expressed in tumours. Here, the authors show that it modulates the activity of lactate dehydrogenase B, resulting in enhanced glycolysis, bio-synthesis and tumour growth.

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Autores principales: Aoxing Cheng, Peng Zhang, Bo Wang, Dongdong Yang, Xiaotao Duan, Yongliang Jiang, Tian Xu, Ya Jiang, Jiahui Shi, Chengtao Ding, Gao Wu, Zhihong Sang, Qiang Wu, Hua Wang, Mian Wu, Zhiyong Zhang, Xin Pan, Yue-yin Pan, Ping Gao, Huafeng Zhang, Cong-zhao Zhou, Jing Guo, Zhenye Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/28e61a5c75424bc9bfb7ba05265c8d1e
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spelling oai:doaj.org-article:28e61a5c75424bc9bfb7ba05265c8d1e2021-12-02T17:02:02ZAurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect10.1038/s41467-019-13485-82041-1723https://doaj.org/article/28e61a5c75424bc9bfb7ba05265c8d1e2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13485-8https://doaj.org/toc/2041-1723Aurora-A kinase is frequently over-expressed in tumours. Here, the authors show that it modulates the activity of lactate dehydrogenase B, resulting in enhanced glycolysis, bio-synthesis and tumour growth.Aoxing ChengPeng ZhangBo WangDongdong YangXiaotao DuanYongliang JiangTian XuYa JiangJiahui ShiChengtao DingGao WuZhihong SangQiang WuHua WangMian WuZhiyong ZhangXin PanYue-yin PanPing GaoHuafeng ZhangCong-zhao ZhouJing GuoZhenye YangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Aoxing Cheng
Peng Zhang
Bo Wang
Dongdong Yang
Xiaotao Duan
Yongliang Jiang
Tian Xu
Ya Jiang
Jiahui Shi
Chengtao Ding
Gao Wu
Zhihong Sang
Qiang Wu
Hua Wang
Mian Wu
Zhiyong Zhang
Xin Pan
Yue-yin Pan
Ping Gao
Huafeng Zhang
Cong-zhao Zhou
Jing Guo
Zhenye Yang
Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect
description Aurora-A kinase is frequently over-expressed in tumours. Here, the authors show that it modulates the activity of lactate dehydrogenase B, resulting in enhanced glycolysis, bio-synthesis and tumour growth.
format article
author Aoxing Cheng
Peng Zhang
Bo Wang
Dongdong Yang
Xiaotao Duan
Yongliang Jiang
Tian Xu
Ya Jiang
Jiahui Shi
Chengtao Ding
Gao Wu
Zhihong Sang
Qiang Wu
Hua Wang
Mian Wu
Zhiyong Zhang
Xin Pan
Yue-yin Pan
Ping Gao
Huafeng Zhang
Cong-zhao Zhou
Jing Guo
Zhenye Yang
author_facet Aoxing Cheng
Peng Zhang
Bo Wang
Dongdong Yang
Xiaotao Duan
Yongliang Jiang
Tian Xu
Ya Jiang
Jiahui Shi
Chengtao Ding
Gao Wu
Zhihong Sang
Qiang Wu
Hua Wang
Mian Wu
Zhiyong Zhang
Xin Pan
Yue-yin Pan
Ping Gao
Huafeng Zhang
Cong-zhao Zhou
Jing Guo
Zhenye Yang
author_sort Aoxing Cheng
title Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect
title_short Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect
title_full Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect
title_fullStr Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect
title_full_unstemmed Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect
title_sort aurora-a mediated phosphorylation of ldhb promotes glycolysis and tumor progression by relieving the substrate-inhibition effect
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/28e61a5c75424bc9bfb7ba05265c8d1e
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