Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications

The ever-growing field of materials with applications in the biomedical field holds great promise regarding the design and fabrication of devices with specific characteristics, especially scaffolds with personalized geometry and architecture. The continuous technological development pushes the limit...

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Autores principales:	Elena Olăreț, Izabela-Cristina Stancu, Horia Iovu, Andrada Serafim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	computed tomography 3D imaging quantitative analysis accurate morphometric characterization Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/28e6d9b55d6e4793b67399911f22ea2e
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spelling	oai:doaj.org-article:28e6d9b55d6e4793b67399911f22ea2e2021-11-25T18:13:22ZComputed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications10.3390/ma142267631996-1944https://doaj.org/article/28e6d9b55d6e4793b67399911f22ea2e2021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/22/6763https://doaj.org/toc/1996-1944The ever-growing field of materials with applications in the biomedical field holds great promise regarding the design and fabrication of devices with specific characteristics, especially scaffolds with personalized geometry and architecture. The continuous technological development pushes the limits of innovation in obtaining adequate scaffolds and establishing their characteristics and performance. To this end, computed tomography (CT) proved to be a reliable, nondestructive, high-performance machine, enabling visualization and structure analysis at submicronic resolutions. CT allows both qualitative and quantitative data of the 3D model, offering an overall image of its specific architectural features and reliable numerical data for rigorous analyses. The precise engineering of scaffolds consists in the fabrication of objects with well-defined morphometric parameters (e.g., shape, porosity, wall thickness) and in their performance validation through thorough control over their behavior (in situ visualization, degradation, new tissue formation, wear, etc.). This review is focused on the use of CT in biomaterial science with the aim of qualitatively and quantitatively assessing the scaffolds’ features and monitoring their behavior following in vivo or in vitro experiments. Furthermore, the paper presents the benefits and limitations regarding the employment of this technique when engineering materials with applications in the biomedical field.Elena OlărețIzabela-Cristina StancuHoria IovuAndrada SerafimMDPI AGarticlecomputed tomography3D imagingquantitative analysisaccurate morphometric characterizationTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6763, p 6763 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	computed tomography 3D imaging quantitative analysis accurate morphometric characterization Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	computed tomography 3D imaging quantitative analysis accurate morphometric characterization Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Elena Olăreț Izabela-Cristina Stancu Horia Iovu Andrada Serafim Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications
description	The ever-growing field of materials with applications in the biomedical field holds great promise regarding the design and fabrication of devices with specific characteristics, especially scaffolds with personalized geometry and architecture. The continuous technological development pushes the limits of innovation in obtaining adequate scaffolds and establishing their characteristics and performance. To this end, computed tomography (CT) proved to be a reliable, nondestructive, high-performance machine, enabling visualization and structure analysis at submicronic resolutions. CT allows both qualitative and quantitative data of the 3D model, offering an overall image of its specific architectural features and reliable numerical data for rigorous analyses. The precise engineering of scaffolds consists in the fabrication of objects with well-defined morphometric parameters (e.g., shape, porosity, wall thickness) and in their performance validation through thorough control over their behavior (in situ visualization, degradation, new tissue formation, wear, etc.). This review is focused on the use of CT in biomaterial science with the aim of qualitatively and quantitatively assessing the scaffolds’ features and monitoring their behavior following in vivo or in vitro experiments. Furthermore, the paper presents the benefits and limitations regarding the employment of this technique when engineering materials with applications in the biomedical field.
format	article
author	Elena Olăreț Izabela-Cristina Stancu Horia Iovu Andrada Serafim
author_facet	Elena Olăreț Izabela-Cristina Stancu Horia Iovu Andrada Serafim
author_sort	Elena Olăreț
title	Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications
title_short	Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications
title_full	Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications
title_fullStr	Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications
title_full_unstemmed	Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications
title_sort	computed tomography as a characterization tool for engineered scaffolds with biomedical applications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/28e6d9b55d6e4793b67399911f22ea2e
work_keys_str_mv	AT elenaolaret computedtomographyasacharacterizationtoolforengineeredscaffoldswithbiomedicalapplications AT izabelacristinastancu computedtomographyasacharacterizationtoolforengineeredscaffoldswithbiomedicalapplications AT horiaiovu computedtomographyasacharacterizationtoolforengineeredscaffoldswithbiomedicalapplications AT andradaserafim computedtomographyasacharacterizationtoolforengineeredscaffoldswithbiomedicalapplications
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Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications

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