Immunofocusing humoral immunity potentiates the functional efficacy of the AnAPN1 malaria transmission-blocking vaccine antigen
Abstract Malaria transmission-blocking vaccines (TBVs) prevent the completion of the developmental lifecycle of malarial parasites within the mosquito vector, effectively blocking subsequent infections. The mosquito midgut protein Anopheline alanyl aminopeptidase N (AnAPN1) is the leading, mosquito-...
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Main Authors: | Nicole G. Bender, Prachi Khare, Juan Martinez, Rebecca E. Tweedell, Vincent O. Nyasembe, Borja López-Gutiérrez, Abhai Tripathi, Dustin Miller, Timothy Hamerly, Eric M. Vela, Ryan R. Davis, Randall F. Howard, Sandrine Nsango, Ronald R. Cobb, Matthias Harbers, Rhoel R. Dinglasan |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2021
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Online Access: | https://doaj.org/article/28e79b6e90d24744bdea15515a7a039e |
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