MUC14-Related ncRNA-mRNA Network in Breast Cancer

<b>Abstract</b>: Background Growing evidences have showed that mucins (MUCs) are linked to occurrence and progression of human cancers. However, a comprehensive study regarding the expression, diagnosis, prognosis and mechanism of MUCs in breast cancer remains absent. <b>Methods:&l...

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Autores principales:	Shuqian Wang, Jing Jin, Jing Chen, Weiyang Lou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mucin 14 (MUC14) noncoding RNA (ncRNA) microRNA (miRNA) breast cancer bioinformatic analysis Genetics QH426-470
Acceso en línea:	https://doaj.org/article/28e9886c578b4fd28e3fc54af20efe35
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spelling	oai:doaj.org-article:28e9886c578b4fd28e3fc54af20efe352021-11-25T17:40:40ZMUC14-Related ncRNA-mRNA Network in Breast Cancer10.3390/genes121116772073-4425https://doaj.org/article/28e9886c578b4fd28e3fc54af20efe352021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1677https://doaj.org/toc/2073-4425<b>Abstract</b>: Background Growing evidences have showed that mucins (MUCs) are linked to occurrence and progression of human cancers. However, a comprehensive study regarding the expression, diagnosis, prognosis and mechanism of MUCs in breast cancer remains absent. <b>Methods:</b> A series of in silico analyses were employed in this study. <b>Results:</b> After performing comprehensive analysis for MUCs, MUC14 was identified as the most potential regulator in breast cancer, with downregulated expression in both mRNA and protein levels and significant diagnostic and prognostic values in breast cancer. Mechanistic exploration revealed that a potential ncRNA-mRNA axis, involving LINC01128/LINC01140/SGMS1-AS1/LINC00667-miR-137/miR-429-BCL2, might be partially responsible for MUC14′s functions in breast cancer. <b>Conclusions:</b> Collectively, our study elucidated a key role of MUC14 in breast cancer and also provided some clues for explanation of the molecular action mechanism of MUC14 in breast cancer.Shuqian WangJing JinJing ChenWeiyang LouMDPI AGarticlemucin 14 (MUC14)noncoding RNA (ncRNA)microRNA (miRNA)breast cancerbioinformatic analysisGeneticsQH426-470ENGenes, Vol 12, Iss 1677, p 1677 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mucin 14 (MUC14) noncoding RNA (ncRNA) microRNA (miRNA) breast cancer bioinformatic analysis Genetics QH426-470
spellingShingle	mucin 14 (MUC14) noncoding RNA (ncRNA) microRNA (miRNA) breast cancer bioinformatic analysis Genetics QH426-470 Shuqian Wang Jing Jin Jing Chen Weiyang Lou MUC14-Related ncRNA-mRNA Network in Breast Cancer
description	<b>Abstract</b>: Background Growing evidences have showed that mucins (MUCs) are linked to occurrence and progression of human cancers. However, a comprehensive study regarding the expression, diagnosis, prognosis and mechanism of MUCs in breast cancer remains absent. <b>Methods:</b> A series of in silico analyses were employed in this study. <b>Results:</b> After performing comprehensive analysis for MUCs, MUC14 was identified as the most potential regulator in breast cancer, with downregulated expression in both mRNA and protein levels and significant diagnostic and prognostic values in breast cancer. Mechanistic exploration revealed that a potential ncRNA-mRNA axis, involving LINC01128/LINC01140/SGMS1-AS1/LINC00667-miR-137/miR-429-BCL2, might be partially responsible for MUC14′s functions in breast cancer. <b>Conclusions:</b> Collectively, our study elucidated a key role of MUC14 in breast cancer and also provided some clues for explanation of the molecular action mechanism of MUC14 in breast cancer.
format	article
author	Shuqian Wang Jing Jin Jing Chen Weiyang Lou
author_facet	Shuqian Wang Jing Jin Jing Chen Weiyang Lou
author_sort	Shuqian Wang
title	MUC14-Related ncRNA-mRNA Network in Breast Cancer
title_short	MUC14-Related ncRNA-mRNA Network in Breast Cancer
title_full	MUC14-Related ncRNA-mRNA Network in Breast Cancer
title_fullStr	MUC14-Related ncRNA-mRNA Network in Breast Cancer
title_full_unstemmed	MUC14-Related ncRNA-mRNA Network in Breast Cancer
title_sort	muc14-related ncrna-mrna network in breast cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/28e9886c578b4fd28e3fc54af20efe35
work_keys_str_mv	AT shuqianwang muc14relatedncrnamrnanetworkinbreastcancer AT jingjin muc14relatedncrnamrnanetworkinbreastcancer AT jingchen muc14relatedncrnamrnanetworkinbreastcancer AT weiyanglou muc14relatedncrnamrnanetworkinbreastcancer
_version_	1718412093709877248

MUC14-Related ncRNA-mRNA Network in Breast Cancer

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