Solitary Rectal Ulcer: A Literature Review

Context Solitary rectal ulcer (SRU) is a disease with many challenging issues. There are several controversies about the basic pathophysiology of this disease. Despite its name, “solitary rectal ulcer”, more than a quarter of patients do not show any ulcer in colonoscopy. Instead, many patients sho...

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Autores principales:	Bita Geramizadeh, Mohammad Baghernezhad, Arezoo Jahanshani Afshar
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2015
Materias:	solitary rectal ulcer iran review Medicine R
Acceso en línea:	https://doaj.org/article/28ea0a2cbfd34f559feaf10c27dbf867
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spelling	oai:doaj.org-article:28ea0a2cbfd34f559feaf10c27dbf8672021-11-15T09:41:07ZSolitary Rectal Ulcer: A Literature Review2783-243010.5812/acr.20749https://doaj.org/article/28ea0a2cbfd34f559feaf10c27dbf8672015-12-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_45504_6b7958fd104a9e5239f35b70701f7dd2.pdfhttps://doaj.org/toc/2783-2430Context Solitary rectal ulcer (SRU) is a disease with many challenging issues. There are several controversies about the basic pathophysiology of this disease. Despite its name, “solitary rectal ulcer”, more than a quarter of patients do not show any ulcer in colonoscopy. Instead, many patients show multiple polypoid lesions. Some previous reports have suggested calling this disease “rectal mucosal prolapse” instead of SRU, however, most of the patients do not have mucosal prolapse. In addition, colonoscopic findings can be very similar to cancer and inflammatory bowel disease, so without histologic evaluation, accurate diagnosis is not always possible. In patients with SRU, sometimes the rectal mucosa is so fibrotic that mucosal biopsy is inadequate, and even a pathologist cannot diagnose the characteristic histologic findings. There are various therapeutic approaches for the treatment of SRU, both surgical and nonsurgical, all of which are not optimal, and recurrence rates are still high with many patients experiencing complications even after surgery, resection and rectopexy. Evidence Acquisition Although this disease is not uncommon in Iran, there are very few studies from Iran, therefore, in this review we will describe our experience with patients with SRU in affiliated hospitals of Shiraz University of Medical Sciences. We will also review previously published articles about SRU that are indexed in PubMed and Google scholar, emphasizing the challenging issues. Results SRU is not an uncommon disease in Iran, however the number of published articles about it, is very low. Multicentric studies are necessary to find out the definite reason of this issue. Conclusions There are still many conflicting controversies about the etiology, pathogenesis, diagnosis and also treatment of SRU, which need further investigation and longer follow up of the patient in each therapeutic approach to be better understood.Bita GeramizadehMohammad BaghernezhadArezoo Jahanshani AfsharShiraz University of Medical Sciencesarticlesolitary rectal ulceriranreviewMedicineRENIranian Journal of Colorectal Research, Vol 3, Iss 4, Pp 0-0 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	solitary rectal ulcer iran review Medicine R
spellingShingle	solitary rectal ulcer iran review Medicine R Bita Geramizadeh Mohammad Baghernezhad Arezoo Jahanshani Afshar Solitary Rectal Ulcer: A Literature Review
description	Context Solitary rectal ulcer (SRU) is a disease with many challenging issues. There are several controversies about the basic pathophysiology of this disease. Despite its name, “solitary rectal ulcer”, more than a quarter of patients do not show any ulcer in colonoscopy. Instead, many patients show multiple polypoid lesions. Some previous reports have suggested calling this disease “rectal mucosal prolapse” instead of SRU, however, most of the patients do not have mucosal prolapse. In addition, colonoscopic findings can be very similar to cancer and inflammatory bowel disease, so without histologic evaluation, accurate diagnosis is not always possible. In patients with SRU, sometimes the rectal mucosa is so fibrotic that mucosal biopsy is inadequate, and even a pathologist cannot diagnose the characteristic histologic findings. There are various therapeutic approaches for the treatment of SRU, both surgical and nonsurgical, all of which are not optimal, and recurrence rates are still high with many patients experiencing complications even after surgery, resection and rectopexy. Evidence Acquisition Although this disease is not uncommon in Iran, there are very few studies from Iran, therefore, in this review we will describe our experience with patients with SRU in affiliated hospitals of Shiraz University of Medical Sciences. We will also review previously published articles about SRU that are indexed in PubMed and Google scholar, emphasizing the challenging issues. Results SRU is not an uncommon disease in Iran, however the number of published articles about it, is very low. Multicentric studies are necessary to find out the definite reason of this issue. Conclusions There are still many conflicting controversies about the etiology, pathogenesis, diagnosis and also treatment of SRU, which need further investigation and longer follow up of the patient in each therapeutic approach to be better understood.
format	article
author	Bita Geramizadeh Mohammad Baghernezhad Arezoo Jahanshani Afshar
author_facet	Bita Geramizadeh Mohammad Baghernezhad Arezoo Jahanshani Afshar
author_sort	Bita Geramizadeh
title	Solitary Rectal Ulcer: A Literature Review
title_short	Solitary Rectal Ulcer: A Literature Review
title_full	Solitary Rectal Ulcer: A Literature Review
title_fullStr	Solitary Rectal Ulcer: A Literature Review
title_full_unstemmed	Solitary Rectal Ulcer: A Literature Review
title_sort	solitary rectal ulcer: a literature review
publisher	Shiraz University of Medical Sciences
publishDate	2015
url	https://doaj.org/article/28ea0a2cbfd34f559feaf10c27dbf867
work_keys_str_mv	AT bitageramizadeh solitaryrectalulceraliteraturereview AT mohammadbaghernezhad solitaryrectalulceraliteraturereview AT arezoojahanshaniafshar solitaryrectalulceraliteraturereview
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Solitary Rectal Ulcer: A Literature Review

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