Functional similarities between pigeon 'milk' and mammalian milk: induction of immune gene expression and modification of the microbiota.

Pigeon 'milk' and mammalian milk have functional similarities in terms of nutritional benefit and delivery of immunoglobulins to the young. Mammalian milk has been clearly shown to aid in the development of the immune system and microbiota of the young, but similar effects have not yet bee...

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Autores principales:	Meagan J Gillespie, Dragana Stanley, Honglei Chen, John A Donald, Kevin R Nicholas, Robert J Moore, Tamsyn M Crowley
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/28ec2c271e4e4c60bb9fad1997719a4e
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spelling	oai:doaj.org-article:28ec2c271e4e4c60bb9fad1997719a4e2021-11-18T08:10:50ZFunctional similarities between pigeon 'milk' and mammalian milk: induction of immune gene expression and modification of the microbiota.1932-620310.1371/journal.pone.0048363https://doaj.org/article/28ec2c271e4e4c60bb9fad1997719a4e2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23110233/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Pigeon 'milk' and mammalian milk have functional similarities in terms of nutritional benefit and delivery of immunoglobulins to the young. Mammalian milk has been clearly shown to aid in the development of the immune system and microbiota of the young, but similar effects have not yet been attributed to pigeon 'milk'. Therefore, using a chicken model, we investigated the effect of pigeon 'milk' on immune gene expression in the Gut Associated Lymphoid Tissue (GALT) and on the composition of the caecal microbiota. Chickens fed pigeon 'milk' had a faster rate of growth and a better feed conversion ratio than control chickens. There was significantly enhanced expression of immune-related gene pathways and interferon-stimulated genes in the GALT of pigeon 'milk'-fed chickens. These pathways include the innate immune response, regulation of cytokine production and regulation of B cell activation and proliferation. The caecal microbiota of pigeon 'milk'-fed chickens was significantly more diverse than control chickens, and appears to be affected by prebiotics in pigeon 'milk', as well as being directly seeded by bacteria present in pigeon 'milk'. Our results demonstrate that pigeon 'milk' has further modes of action which make it functionally similar to mammalian milk. We hypothesise that pigeon 'lactation' and mammalian lactation evolved independently but resulted in similarly functional products.Meagan J GillespieDragana StanleyHonglei ChenJohn A DonaldKevin R NicholasRobert J MooreTamsyn M CrowleyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e48363 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Meagan J Gillespie Dragana Stanley Honglei Chen John A Donald Kevin R Nicholas Robert J Moore Tamsyn M Crowley Functional similarities between pigeon 'milk' and mammalian milk: induction of immune gene expression and modification of the microbiota.
description	Pigeon 'milk' and mammalian milk have functional similarities in terms of nutritional benefit and delivery of immunoglobulins to the young. Mammalian milk has been clearly shown to aid in the development of the immune system and microbiota of the young, but similar effects have not yet been attributed to pigeon 'milk'. Therefore, using a chicken model, we investigated the effect of pigeon 'milk' on immune gene expression in the Gut Associated Lymphoid Tissue (GALT) and on the composition of the caecal microbiota. Chickens fed pigeon 'milk' had a faster rate of growth and a better feed conversion ratio than control chickens. There was significantly enhanced expression of immune-related gene pathways and interferon-stimulated genes in the GALT of pigeon 'milk'-fed chickens. These pathways include the innate immune response, regulation of cytokine production and regulation of B cell activation and proliferation. The caecal microbiota of pigeon 'milk'-fed chickens was significantly more diverse than control chickens, and appears to be affected by prebiotics in pigeon 'milk', as well as being directly seeded by bacteria present in pigeon 'milk'. Our results demonstrate that pigeon 'milk' has further modes of action which make it functionally similar to mammalian milk. We hypothesise that pigeon 'lactation' and mammalian lactation evolved independently but resulted in similarly functional products.
format	article
author	Meagan J Gillespie Dragana Stanley Honglei Chen John A Donald Kevin R Nicholas Robert J Moore Tamsyn M Crowley
author_facet	Meagan J Gillespie Dragana Stanley Honglei Chen John A Donald Kevin R Nicholas Robert J Moore Tamsyn M Crowley
author_sort	Meagan J Gillespie
title	Functional similarities between pigeon 'milk' and mammalian milk: induction of immune gene expression and modification of the microbiota.
title_short	Functional similarities between pigeon 'milk' and mammalian milk: induction of immune gene expression and modification of the microbiota.
title_full	Functional similarities between pigeon 'milk' and mammalian milk: induction of immune gene expression and modification of the microbiota.
title_fullStr	Functional similarities between pigeon 'milk' and mammalian milk: induction of immune gene expression and modification of the microbiota.
title_full_unstemmed	Functional similarities between pigeon 'milk' and mammalian milk: induction of immune gene expression and modification of the microbiota.
title_sort	functional similarities between pigeon 'milk' and mammalian milk: induction of immune gene expression and modification of the microbiota.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/28ec2c271e4e4c60bb9fad1997719a4e
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Functional similarities between pigeon 'milk' and mammalian milk: induction of immune gene expression and modification of the microbiota.

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