A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction

A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction

Osteocytes are mechanoresponsive within skeletal tissue. Here, the authors show that class IIa histone deacetylases are phosphorylated by focal adhesion kinase, suggesting that HDAC5 may propagate mechanobiological cues to regulate cell type-specific gene expression.

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Detalles Bibliográficos
Autores principales: Tadatoshi Sato, Shiv Verma, Christian D. Castro Andrade, Maureen Omeara, Nia Campbell, Jialiang S. Wang, Murat Cetinbas, Audrey Lang, Brandon J. Ausk, Daniel J. Brooks, Ruslan I. Sadreyev, Henry M. Kronenberg, David Lagares, Yuhei Uda, Paola Divieti Pajevic, Mary L. Bouxsein, Ted S. Gross, Marc N. Wein
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/28efc06b6072451db15433775595a921
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Descripción
Sumario:Osteocytes are mechanoresponsive within skeletal tissue. Here, the authors show that class IIa histone deacetylases are phosphorylated by focal adhesion kinase, suggesting that HDAC5 may propagate mechanobiological cues to regulate cell type-specific gene expression.

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