A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction
Osteocytes are mechanoresponsive within skeletal tissue. Here, the authors show that class IIa histone deacetylases are phosphorylated by focal adhesion kinase, suggesting that HDAC5 may propagate mechanobiological cues to regulate cell type-specific gene expression.
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Nature Portfolio
2020
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| Acceso en línea: | https://doaj.org/article/28efc06b6072451db15433775595a921 |
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oai:doaj.org-article:28efc06b6072451db15433775595a9212021-12-02T14:34:06ZA FAK/HDAC5 signaling axis controls osteocyte mechanotransduction10.1038/s41467-020-17099-32041-1723https://doaj.org/article/28efc06b6072451db15433775595a9212020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17099-3https://doaj.org/toc/2041-1723Osteocytes are mechanoresponsive within skeletal tissue. Here, the authors show that class IIa histone deacetylases are phosphorylated by focal adhesion kinase, suggesting that HDAC5 may propagate mechanobiological cues to regulate cell type-specific gene expression.Tadatoshi SatoShiv VermaChristian D. Castro AndradeMaureen OmearaNia CampbellJialiang S. WangMurat CetinbasAudrey LangBrandon J. AuskDaniel J. BrooksRuslan I. SadreyevHenry M. KronenbergDavid LagaresYuhei UdaPaola Divieti PajevicMary L. BouxseinTed S. GrossMarc N. WeinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Tadatoshi Sato Shiv Verma Christian D. Castro Andrade Maureen Omeara Nia Campbell Jialiang S. Wang Murat Cetinbas Audrey Lang Brandon J. Ausk Daniel J. Brooks Ruslan I. Sadreyev Henry M. Kronenberg David Lagares Yuhei Uda Paola Divieti Pajevic Mary L. Bouxsein Ted S. Gross Marc N. Wein A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction |
| description |
Osteocytes are mechanoresponsive within skeletal tissue. Here, the authors show that class IIa histone deacetylases are phosphorylated by focal adhesion kinase, suggesting that HDAC5 may propagate mechanobiological cues to regulate cell type-specific gene expression. |
| format |
article |
| author |
Tadatoshi Sato Shiv Verma Christian D. Castro Andrade Maureen Omeara Nia Campbell Jialiang S. Wang Murat Cetinbas Audrey Lang Brandon J. Ausk Daniel J. Brooks Ruslan I. Sadreyev Henry M. Kronenberg David Lagares Yuhei Uda Paola Divieti Pajevic Mary L. Bouxsein Ted S. Gross Marc N. Wein |
| author_facet |
Tadatoshi Sato Shiv Verma Christian D. Castro Andrade Maureen Omeara Nia Campbell Jialiang S. Wang Murat Cetinbas Audrey Lang Brandon J. Ausk Daniel J. Brooks Ruslan I. Sadreyev Henry M. Kronenberg David Lagares Yuhei Uda Paola Divieti Pajevic Mary L. Bouxsein Ted S. Gross Marc N. Wein |
| author_sort |
Tadatoshi Sato |
| title |
A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction |
| title_short |
A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction |
| title_full |
A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction |
| title_fullStr |
A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction |
| title_full_unstemmed |
A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction |
| title_sort |
fak/hdac5 signaling axis controls osteocyte mechanotransduction |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/28efc06b6072451db15433775595a921 |
| work_keys_str_mv |
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| _version_ |
1718391118274494464 |