Treatment of oral squamous cell carcinoma using anti-HER2 immunonanoshells

Reza Fekrazad2, Neda Hakimiha3, Enice Farokhi3, Mohammad Javad Rasaee4, Mehdi Shafiee Ardestani5, Katayoun AM Kalhori2, Farzaneh Sheikholeslami1 1Research &amp; Development Department, Production and Research Division of the Pasteur Institute of Iran, Karaj, Iran; 2Dental Department, AJA Uni...

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Autores principales:	Fekrazad R, Hakimiha N, Farokhi E, Rasaee MJ, Ardestani MS, Kalhori KA, Sheikholeslami F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/28efcf360ac843c2a9f0bea68d3e0a50
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spelling	oai:doaj.org-article:28efcf360ac843c2a9f0bea68d3e0a502021-12-02T05:40:39ZTreatment of oral squamous cell carcinoma using anti-HER2 immunonanoshells1176-91141178-2013https://doaj.org/article/28efcf360ac843c2a9f0bea68d3e0a502011-11-01T00:00:00Zhttp://www.dovepress.com/treatment-of-oral-squamous-cell-carcinoma-using-anti-her2-immunonanosh-a8630https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Reza Fekrazad2, Neda Hakimiha3, Enice Farokhi3, Mohammad Javad Rasaee4, Mehdi Shafiee Ardestani5, Katayoun AM Kalhori2, Farzaneh Sheikholeslami1 1Research &amp; Development Department, Production and Research Division of the Pasteur Institute of Iran, Karaj, Iran; 2Dental Department, AJA University of Medical Sciences, Laser Research Center, Dental Faculty, Tehran University of Medical Sciences; 3Dentistry Department, Faculty of Dentistry, Shahed University, Tehran, Iran; 4Department of Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; 5Hepatitis and AIDS Department, Pasteur Institute of Iran, Tehran Background: Worldwide, oral squamous cell carcinoma (potentially mediated by HER2) is recognized as the most commonly occurring malignant neoplasm of the oral cavity. Anti-HER2 nanobodies conjugated to gold-silica nanoshells and used as photothermal treatment for oral squamous cell carcinoma may provide a novel therapeutic alternative to current treatment for this disease. Methods: KB epithelial or HeLaS3 cell cultures (controls) were exposed to these immunonanoshells, and plasmon resonance electron initiation specific to gold was employed to burn the tumor cells. Results: Following this treatment, significant cell death occurred in the KB tumor cell cultures while there was no evidence of cellular damage or death in the HeLaS3 cell cultures. Conclusion: These findings suggest that photothermal treatment of oral squamous cell carcinoma has considerable advantages. Keywords: anti-HER2 immunonanoshells, gold-silica nanoshells, photothermal treatment, oral squamous cell carcinomaFekrazad RHakimiha NFarokhi ERasaee MJArdestani MSKalhori KASheikholeslami FDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 2749-2755 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Fekrazad R Hakimiha N Farokhi E Rasaee MJ Ardestani MS Kalhori KA Sheikholeslami F Treatment of oral squamous cell carcinoma using anti-HER2 immunonanoshells
description	Reza Fekrazad2, Neda Hakimiha3, Enice Farokhi3, Mohammad Javad Rasaee4, Mehdi Shafiee Ardestani5, Katayoun AM Kalhori2, Farzaneh Sheikholeslami1 1Research &amp; Development Department, Production and Research Division of the Pasteur Institute of Iran, Karaj, Iran; 2Dental Department, AJA University of Medical Sciences, Laser Research Center, Dental Faculty, Tehran University of Medical Sciences; 3Dentistry Department, Faculty of Dentistry, Shahed University, Tehran, Iran; 4Department of Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; 5Hepatitis and AIDS Department, Pasteur Institute of Iran, Tehran Background: Worldwide, oral squamous cell carcinoma (potentially mediated by HER2) is recognized as the most commonly occurring malignant neoplasm of the oral cavity. Anti-HER2 nanobodies conjugated to gold-silica nanoshells and used as photothermal treatment for oral squamous cell carcinoma may provide a novel therapeutic alternative to current treatment for this disease. Methods: KB epithelial or HeLaS3 cell cultures (controls) were exposed to these immunonanoshells, and plasmon resonance electron initiation specific to gold was employed to burn the tumor cells. Results: Following this treatment, significant cell death occurred in the KB tumor cell cultures while there was no evidence of cellular damage or death in the HeLaS3 cell cultures. Conclusion: These findings suggest that photothermal treatment of oral squamous cell carcinoma has considerable advantages. Keywords: anti-HER2 immunonanoshells, gold-silica nanoshells, photothermal treatment, oral squamous cell carcinoma
format	article
author	Fekrazad R Hakimiha N Farokhi E Rasaee MJ Ardestani MS Kalhori KA Sheikholeslami F
author_facet	Fekrazad R Hakimiha N Farokhi E Rasaee MJ Ardestani MS Kalhori KA Sheikholeslami F
author_sort	Fekrazad R
title	Treatment of oral squamous cell carcinoma using anti-HER2 immunonanoshells
title_short	Treatment of oral squamous cell carcinoma using anti-HER2 immunonanoshells
title_full	Treatment of oral squamous cell carcinoma using anti-HER2 immunonanoshells
title_fullStr	Treatment of oral squamous cell carcinoma using anti-HER2 immunonanoshells
title_full_unstemmed	Treatment of oral squamous cell carcinoma using anti-HER2 immunonanoshells
title_sort	treatment of oral squamous cell carcinoma using anti-her2 immunonanoshells
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/28efcf360ac843c2a9f0bea68d3e0a50
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Treatment of oral squamous cell carcinoma using anti-HER2 immunonanoshells

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