Cyclosporine treatment reduces oxygen free radical generation and oxidative stress in the brain of hypoxia-reoxygenated newborn piglets.

Oxygen free radicals have been implicated in the pathogenesis of hypoxic-ischemic encephalopathy. It has previously been shown in traumatic brain injury animal models that treatment with cyclosporine reduces brain injury. However, the potential neuroprotective effect of cyclosporine in asphyxiated n...

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Main Authors: Richdeep S Gill, Tze-Fun Lee, Jiang-Qin Liu, Hetal Chaudhary, Dion R Brocks, David L Bigam, Po-Yin Cheung
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
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Online Access:https://doaj.org/article/28f0f5c2281d48cda923f1796156991d
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