Dynamic tuneable G protein-coupled receptor monomer-dimer populations

Evidence suggests oligomerisation of G protein-coupled receptors in membranes, but this is controversial. Here, authors use single-molecule and ensemble FRET, and spectroscopy to show that the neurotensin receptor 1 forms multiple dimer conformations that interconvert - “rolling” interfaces.

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Autores principales:	Patricia M. Dijkman, Oliver K. Castell, Alan D. Goddard, Juan C. Munoz-Garcia, Chris de Graaf, Mark I. Wallace, Anthony Watts
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/28f2d38675864c7fa3f3f5c8d36e8dc1
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spelling	oai:doaj.org-article:28f2d38675864c7fa3f3f5c8d36e8dc12021-12-02T15:33:46ZDynamic tuneable G protein-coupled receptor monomer-dimer populations10.1038/s41467-018-03727-62041-1723https://doaj.org/article/28f2d38675864c7fa3f3f5c8d36e8dc12018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03727-6https://doaj.org/toc/2041-1723Evidence suggests oligomerisation of G protein-coupled receptors in membranes, but this is controversial. Here, authors use single-molecule and ensemble FRET, and spectroscopy to show that the neurotensin receptor 1 forms multiple dimer conformations that interconvert - “rolling” interfaces.Patricia M. DijkmanOliver K. CastellAlan D. GoddardJuan C. Munoz-GarciaChris de GraafMark I. WallaceAnthony WattsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patricia M. Dijkman Oliver K. Castell Alan D. Goddard Juan C. Munoz-Garcia Chris de Graaf Mark I. Wallace Anthony Watts Dynamic tuneable G protein-coupled receptor monomer-dimer populations
description	Evidence suggests oligomerisation of G protein-coupled receptors in membranes, but this is controversial. Here, authors use single-molecule and ensemble FRET, and spectroscopy to show that the neurotensin receptor 1 forms multiple dimer conformations that interconvert - “rolling” interfaces.
format	article
author	Patricia M. Dijkman Oliver K. Castell Alan D. Goddard Juan C. Munoz-Garcia Chris de Graaf Mark I. Wallace Anthony Watts
author_facet	Patricia M. Dijkman Oliver K. Castell Alan D. Goddard Juan C. Munoz-Garcia Chris de Graaf Mark I. Wallace Anthony Watts
author_sort	Patricia M. Dijkman
title	Dynamic tuneable G protein-coupled receptor monomer-dimer populations
title_short	Dynamic tuneable G protein-coupled receptor monomer-dimer populations
title_full	Dynamic tuneable G protein-coupled receptor monomer-dimer populations
title_fullStr	Dynamic tuneable G protein-coupled receptor monomer-dimer populations
title_full_unstemmed	Dynamic tuneable G protein-coupled receptor monomer-dimer populations
title_sort	dynamic tuneable g protein-coupled receptor monomer-dimer populations
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/28f2d38675864c7fa3f3f5c8d36e8dc1
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Dynamic tuneable G protein-coupled receptor monomer-dimer populations

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