Antitumor Effects of Evodiamine in Mice Model Experiments: A Systematic Review and Meta-Analysis

BackgroundEvodiamine (EVO), an alkaloid extracted from the traditional Chinese medicine Euodia rutaecarpa, plays an important role in the treatment of cancer. This study was performed to clarify the effects of evodiamine in mice tumor model studies.MethodsElectronic databases and search engines invo...

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Autores principales:	Cong Yin, Jing Cheng, Hongbing Peng, Shijun Yuan, Keli Chen, Juan Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	evodiamine tumor systematic review meta-analysis mice model experiments Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/28f3a3cd3950456fbb7796d6c863a1b5
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spelling	oai:doaj.org-article:28f3a3cd3950456fbb7796d6c863a1b52021-11-09T05:19:36ZAntitumor Effects of Evodiamine in Mice Model Experiments: A Systematic Review and Meta-Analysis2234-943X10.3389/fonc.2021.774201https://doaj.org/article/28f3a3cd3950456fbb7796d6c863a1b52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.774201/fullhttps://doaj.org/toc/2234-943XBackgroundEvodiamine (EVO), an alkaloid extracted from the traditional Chinese medicine Euodia rutaecarpa, plays an important role in the treatment of cancer. This study was performed to clarify the effects of evodiamine in mice tumor model studies.MethodsElectronic databases and search engines involved China Knowledge Resource Integrated Database (CNKI), Wanfang Database, Chinese Scientific Journal Database (CSJD-VIP), China Biomedical Literature Database (CBM), PubMed, Embase, Web of Science, and ClinicalTrials.gov databases, which were searched for literature related to the antitumor effects of evodiamine in animal tumor models (all until 1 October 2021). The evodiamine effects on the tumor volume and tumor weight were compared between the treatment and control groups using the standardized mean difference (SMD).ResultsEvodiamine significantly inhibited tumor growth in mice, as was assessed with tumor volume [13 studies, n=267; 138 for EVO and 129 for control; standard mean difference (SMD)= -5.99; 95% (CI): -8.89 to -3.10; I2 = 97.69%, p ≤ 0.00], tumor weight [6 studies, n=89; 49 for EVO and 40 for control; standard mean difference (SMD)= -3.51; 95% (CI): -5.13 to -3.90; I2 = 83.02%, p ≤ 0.00].ConclusionEVO significantly suppresses tumor growth in mice models, which would be beneficial for clinical transformation. However, due to the small number of studies included in this meta-analysis, the experimental design and experimental method limitations should be considered when interpreting the results. Significant clinical and animal studies are still required to evaluate whether EVO can be used in the adjuvant treatment of clinical tumor patients.Cong YinJing ChengHongbing PengShijun YuanKeli ChenJuan LiFrontiers Media S.A.articleevodiaminetumorsystematic reviewmeta-analysismice model experimentsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	evodiamine tumor systematic review meta-analysis mice model experiments Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	evodiamine tumor systematic review meta-analysis mice model experiments Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cong Yin Jing Cheng Hongbing Peng Shijun Yuan Keli Chen Juan Li Antitumor Effects of Evodiamine in Mice Model Experiments: A Systematic Review and Meta-Analysis
description	BackgroundEvodiamine (EVO), an alkaloid extracted from the traditional Chinese medicine Euodia rutaecarpa, plays an important role in the treatment of cancer. This study was performed to clarify the effects of evodiamine in mice tumor model studies.MethodsElectronic databases and search engines involved China Knowledge Resource Integrated Database (CNKI), Wanfang Database, Chinese Scientific Journal Database (CSJD-VIP), China Biomedical Literature Database (CBM), PubMed, Embase, Web of Science, and ClinicalTrials.gov databases, which were searched for literature related to the antitumor effects of evodiamine in animal tumor models (all until 1 October 2021). The evodiamine effects on the tumor volume and tumor weight were compared between the treatment and control groups using the standardized mean difference (SMD).ResultsEvodiamine significantly inhibited tumor growth in mice, as was assessed with tumor volume [13 studies, n=267; 138 for EVO and 129 for control; standard mean difference (SMD)= -5.99; 95% (CI): -8.89 to -3.10; I2 = 97.69%, p ≤ 0.00], tumor weight [6 studies, n=89; 49 for EVO and 40 for control; standard mean difference (SMD)= -3.51; 95% (CI): -5.13 to -3.90; I2 = 83.02%, p ≤ 0.00].ConclusionEVO significantly suppresses tumor growth in mice models, which would be beneficial for clinical transformation. However, due to the small number of studies included in this meta-analysis, the experimental design and experimental method limitations should be considered when interpreting the results. Significant clinical and animal studies are still required to evaluate whether EVO can be used in the adjuvant treatment of clinical tumor patients.
format	article
author	Cong Yin Jing Cheng Hongbing Peng Shijun Yuan Keli Chen Juan Li
author_facet	Cong Yin Jing Cheng Hongbing Peng Shijun Yuan Keli Chen Juan Li
author_sort	Cong Yin
title	Antitumor Effects of Evodiamine in Mice Model Experiments: A Systematic Review and Meta-Analysis
title_short	Antitumor Effects of Evodiamine in Mice Model Experiments: A Systematic Review and Meta-Analysis
title_full	Antitumor Effects of Evodiamine in Mice Model Experiments: A Systematic Review and Meta-Analysis
title_fullStr	Antitumor Effects of Evodiamine in Mice Model Experiments: A Systematic Review and Meta-Analysis
title_full_unstemmed	Antitumor Effects of Evodiamine in Mice Model Experiments: A Systematic Review and Meta-Analysis
title_sort	antitumor effects of evodiamine in mice model experiments: a systematic review and meta-analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/28f3a3cd3950456fbb7796d6c863a1b5
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Antitumor Effects of Evodiamine in Mice Model Experiments: A Systematic Review and Meta-Analysis

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