STUDIES OF INNATE IMMUNITY PARAMETERS (TLR2, TLR4 AND HBD1) OF URETHERAL MUCOUS EPITHELIUM IN CHRONIC BACTERIAL CYSTITIS

The study for quantitation of TLR2, TLR4 and HBD-1 gene expression in urethral mucosal epithelium from women with chronic bacterial cystitis and healthy females. Materials and methods: RNA was extracted from the samples of urethral mucosa followed by RT-PCR. Results: increased expression of TLR2, TL...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	O. A. Svitich, L. V. Gankovskaya, A. V. Berenshtein, T. S. Perepanova, E. M. Volkova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	innate immunity mucosa urinary tract infections toll-like receptors defensins Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/28f3a80f4916433f93d69c847edab8e2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:28f3a80f4916433f93d69c847edab8e2
record_format	dspace
spelling	oai:doaj.org-article:28f3a80f4916433f93d69c847edab8e22021-11-18T08:03:45ZSTUDIES OF INNATE IMMUNITY PARAMETERS (TLR2, TLR4 AND HBD1) OF URETHERAL MUCOUS EPITHELIUM IN CHRONIC BACTERIAL CYSTITIS1563-06252313-741X10.15789/1563-0625-2016-5-469-474https://doaj.org/article/28f3a80f4916433f93d69c847edab8e22016-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1072https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe study for quantitation of TLR2, TLR4 and HBD-1 gene expression in urethral mucosal epithelium from women with chronic bacterial cystitis and healthy females. Materials and methods: RNA was extracted from the samples of urethral mucosa followed by RT-PCR. Results: increased expression of TLR2, TLR4 (respectively, 6.9-, 2.6-fold), along with 13.6-fold decrease in HBD-1 was revealed in women with chronic bacterial cystitis, as compared with appropriate parameters in normal women. Six months later, after combined therapy with autologous immunopeptide complex, TLR2, TLR4 и HBD1 expression levels proved to be near-normal in the patients, being similar to those in healthy females. Conclusion: Imbalanced expression of genes controlling innate immunity was revealed in urethral mucosa of the patients with chronic cystitis, thus increasing risk for urinary tract infections.O. A. SvitichL. V. GankovskayaA. V. BerenshteinT. S. PerepanovaE. M. VolkovaSPb RAACIarticleinnate immunitymucosaurinary tract infectionstoll-like receptorsdefensinsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 5, Pp 469-474 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	innate immunity mucosa urinary tract infections toll-like receptors defensins Immunologic diseases. Allergy RC581-607
spellingShingle	innate immunity mucosa urinary tract infections toll-like receptors defensins Immunologic diseases. Allergy RC581-607 O. A. Svitich L. V. Gankovskaya A. V. Berenshtein T. S. Perepanova E. M. Volkova STUDIES OF INNATE IMMUNITY PARAMETERS (TLR2, TLR4 AND HBD1) OF URETHERAL MUCOUS EPITHELIUM IN CHRONIC BACTERIAL CYSTITIS
description	The study for quantitation of TLR2, TLR4 and HBD-1 gene expression in urethral mucosal epithelium from women with chronic bacterial cystitis and healthy females. Materials and methods: RNA was extracted from the samples of urethral mucosa followed by RT-PCR. Results: increased expression of TLR2, TLR4 (respectively, 6.9-, 2.6-fold), along with 13.6-fold decrease in HBD-1 was revealed in women with chronic bacterial cystitis, as compared with appropriate parameters in normal women. Six months later, after combined therapy with autologous immunopeptide complex, TLR2, TLR4 и HBD1 expression levels proved to be near-normal in the patients, being similar to those in healthy females. Conclusion: Imbalanced expression of genes controlling innate immunity was revealed in urethral mucosa of the patients with chronic cystitis, thus increasing risk for urinary tract infections.
format	article
author	O. A. Svitich L. V. Gankovskaya A. V. Berenshtein T. S. Perepanova E. M. Volkova
author_facet	O. A. Svitich L. V. Gankovskaya A. V. Berenshtein T. S. Perepanova E. M. Volkova
author_sort	O. A. Svitich
title	STUDIES OF INNATE IMMUNITY PARAMETERS (TLR2, TLR4 AND HBD1) OF URETHERAL MUCOUS EPITHELIUM IN CHRONIC BACTERIAL CYSTITIS
title_short	STUDIES OF INNATE IMMUNITY PARAMETERS (TLR2, TLR4 AND HBD1) OF URETHERAL MUCOUS EPITHELIUM IN CHRONIC BACTERIAL CYSTITIS
title_full	STUDIES OF INNATE IMMUNITY PARAMETERS (TLR2, TLR4 AND HBD1) OF URETHERAL MUCOUS EPITHELIUM IN CHRONIC BACTERIAL CYSTITIS
title_fullStr	STUDIES OF INNATE IMMUNITY PARAMETERS (TLR2, TLR4 AND HBD1) OF URETHERAL MUCOUS EPITHELIUM IN CHRONIC BACTERIAL CYSTITIS
title_full_unstemmed	STUDIES OF INNATE IMMUNITY PARAMETERS (TLR2, TLR4 AND HBD1) OF URETHERAL MUCOUS EPITHELIUM IN CHRONIC BACTERIAL CYSTITIS
title_sort	studies of innate immunity parameters (tlr2, tlr4 and hbd1) of uretheral mucous epithelium in chronic bacterial cystitis
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/28f3a80f4916433f93d69c847edab8e2
work_keys_str_mv	AT oasvitich studiesofinnateimmunityparameterstlr2tlr4andhbd1ofuretheralmucousepitheliuminchronicbacterialcystitis AT lvgankovskaya studiesofinnateimmunityparameterstlr2tlr4andhbd1ofuretheralmucousepitheliuminchronicbacterialcystitis AT avberenshtein studiesofinnateimmunityparameterstlr2tlr4andhbd1ofuretheralmucousepitheliuminchronicbacterialcystitis AT tsperepanova studiesofinnateimmunityparameterstlr2tlr4andhbd1ofuretheralmucousepitheliuminchronicbacterialcystitis AT emvolkova studiesofinnateimmunityparameterstlr2tlr4andhbd1ofuretheralmucousepitheliuminchronicbacterialcystitis
_version_	1718422404883021824

STUDIES OF INNATE IMMUNITY PARAMETERS (TLR2, TLR4 AND HBD1) OF URETHERAL MUCOUS EPITHELIUM IN CHRONIC BACTERIAL CYSTITIS

Ejemplares similares