14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains

Pohl et al. investigated the structural basis of Nedd4-2 regulation by 14-3-3 and found that phosphorylated Ser342 and Ser448 are the main residues that facilitate 14-3-3 binding to Nedd4-2. The authors propose that the Nedd4-2:14-3-3 complex then stimulates a structural rearrangement of Nedd4-2 thr...

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Autores principales:	Pavel Pohl, Rohit Joshi, Olivia Petrvalska, Tomas Obsil, Veronika Obsilova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/28f3af453a79406099b6b0c5ec6e9945
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spelling	oai:doaj.org-article:28f3af453a79406099b6b0c5ec6e99452021-12-02T16:26:28Z14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains10.1038/s42003-021-02419-02399-3642https://doaj.org/article/28f3af453a79406099b6b0c5ec6e99452021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02419-0https://doaj.org/toc/2399-3642Pohl et al. investigated the structural basis of Nedd4-2 regulation by 14-3-3 and found that phosphorylated Ser342 and Ser448 are the main residues that facilitate 14-3-3 binding to Nedd4-2. The authors propose that the Nedd4-2:14-3-3 complex then stimulates a structural rearrangement of Nedd4-2 through inhibiting interaction of its structured domains.Pavel PohlRohit JoshiOlivia PetrvalskaTomas ObsilVeronika ObsilovaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Pavel Pohl Rohit Joshi Olivia Petrvalska Tomas Obsil Veronika Obsilova 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains
description	Pohl et al. investigated the structural basis of Nedd4-2 regulation by 14-3-3 and found that phosphorylated Ser342 and Ser448 are the main residues that facilitate 14-3-3 binding to Nedd4-2. The authors propose that the Nedd4-2:14-3-3 complex then stimulates a structural rearrangement of Nedd4-2 through inhibiting interaction of its structured domains.
format	article
author	Pavel Pohl Rohit Joshi Olivia Petrvalska Tomas Obsil Veronika Obsilova
author_facet	Pavel Pohl Rohit Joshi Olivia Petrvalska Tomas Obsil Veronika Obsilova
author_sort	Pavel Pohl
title	14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains
title_short	14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains
title_full	14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains
title_fullStr	14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains
title_full_unstemmed	14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains
title_sort	14-3-3-protein regulates nedd4-2 by modulating interactions between hect and ww domains
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/28f3af453a79406099b6b0c5ec6e9945
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14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains

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