The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis

Although CTCF is a well-established 3D chromatin organizer in multicellular eukaryotes, relatively little is known about its male germ cell-specific paralogue, BORIS. Here the authors investigate how CTCF and BORIS interact and compensate in the male germline of mice to ensure appropriate activation...

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Autores principales: Samuel Rivero-Hinojosa, Elena M. Pugacheva, Sungyun Kang, Claudia Fabiola Méndez-Catalá, Alexander L. Kovalchuk, Alexander V. Strunnikov, Dmitri Loukinov, Jeannie T. Lee, Victor V. Lobanenkov
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/28f4c6cce58c4b69bfa80168060ded84
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Sumario:Although CTCF is a well-established 3D chromatin organizer in multicellular eukaryotes, relatively little is known about its male germ cell-specific paralogue, BORIS. Here the authors investigate how CTCF and BORIS interact and compensate in the male germline of mice to ensure appropriate activation of spermatogenesis-specific genes.