The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis

Although CTCF is a well-established 3D chromatin organizer in multicellular eukaryotes, relatively little is known about its male germ cell-specific paralogue, BORIS. Here the authors investigate how CTCF and BORIS interact and compensate in the male germline of mice to ensure appropriate activation...

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Autores principales:	Samuel Rivero-Hinojosa, Elena M. Pugacheva, Sungyun Kang, Claudia Fabiola Méndez-Catalá, Alexander L. Kovalchuk, Alexander V. Strunnikov, Dmitri Loukinov, Jeannie T. Lee, Victor V. Lobanenkov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/28f4c6cce58c4b69bfa80168060ded84
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spelling	oai:doaj.org-article:28f4c6cce58c4b69bfa80168060ded842021-12-02T17:12:20ZThe combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis10.1038/s41467-021-24140-62041-1723https://doaj.org/article/28f4c6cce58c4b69bfa80168060ded842021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24140-6https://doaj.org/toc/2041-1723Although CTCF is a well-established 3D chromatin organizer in multicellular eukaryotes, relatively little is known about its male germ cell-specific paralogue, BORIS. Here the authors investigate how CTCF and BORIS interact and compensate in the male germline of mice to ensure appropriate activation of spermatogenesis-specific genes.Samuel Rivero-HinojosaElena M. PugachevaSungyun KangClaudia Fabiola Méndez-CataláAlexander L. KovalchukAlexander V. StrunnikovDmitri LoukinovJeannie T. LeeVictor V. LobanenkovNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Samuel Rivero-Hinojosa Elena M. Pugacheva Sungyun Kang Claudia Fabiola Méndez-Catalá Alexander L. Kovalchuk Alexander V. Strunnikov Dmitri Loukinov Jeannie T. Lee Victor V. Lobanenkov The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis
description	Although CTCF is a well-established 3D chromatin organizer in multicellular eukaryotes, relatively little is known about its male germ cell-specific paralogue, BORIS. Here the authors investigate how CTCF and BORIS interact and compensate in the male germline of mice to ensure appropriate activation of spermatogenesis-specific genes.
format	article
author	Samuel Rivero-Hinojosa Elena M. Pugacheva Sungyun Kang Claudia Fabiola Méndez-Catalá Alexander L. Kovalchuk Alexander V. Strunnikov Dmitri Loukinov Jeannie T. Lee Victor V. Lobanenkov
author_facet	Samuel Rivero-Hinojosa Elena M. Pugacheva Sungyun Kang Claudia Fabiola Méndez-Catalá Alexander L. Kovalchuk Alexander V. Strunnikov Dmitri Loukinov Jeannie T. Lee Victor V. Lobanenkov
author_sort	Samuel Rivero-Hinojosa
title	The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis
title_short	The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis
title_full	The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis
title_fullStr	The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis
title_full_unstemmed	The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis
title_sort	combined action of ctcf and its testis-specific paralog boris is essential for spermatogenesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/28f4c6cce58c4b69bfa80168060ded84
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The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis

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