Identification of disease treatment mechanisms through the multiscale interactome

Most diseases disrupt multiple proteins, and drugs treat such diseases by restoring the functions of the disrupted proteins; how drugs restore these functions, however, is often unknown. Here, the authors develop the multiscale interactome, a powerful approach to explain disease treatment.

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Bibliographic Details
Main Authors: Camilo Ruiz, Marinka Zitnik, Jure Leskovec
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/28f8ca7de94d4f08a6693d3cd37dc25a
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Summary:Most diseases disrupt multiple proteins, and drugs treat such diseases by restoring the functions of the disrupted proteins; how drugs restore these functions, however, is often unknown. Here, the authors develop the multiscale interactome, a powerful approach to explain disease treatment.