Identification of disease treatment mechanisms through the multiscale interactome

Most diseases disrupt multiple proteins, and drugs treat such diseases by restoring the functions of the disrupted proteins; how drugs restore these functions, however, is often unknown. Here, the authors develop the multiscale interactome, a powerful approach to explain disease treatment.

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Detalles Bibliográficos
Autores principales:	Camilo Ruiz, Marinka Zitnik, Jure Leskovec
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/28f8ca7de94d4f08a6693d3cd37dc25a
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spelling	oai:doaj.org-article:28f8ca7de94d4f08a6693d3cd37dc25a2021-12-02T17:03:35ZIdentification of disease treatment mechanisms through the multiscale interactome10.1038/s41467-021-21770-82041-1723https://doaj.org/article/28f8ca7de94d4f08a6693d3cd37dc25a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21770-8https://doaj.org/toc/2041-1723Most diseases disrupt multiple proteins, and drugs treat such diseases by restoring the functions of the disrupted proteins; how drugs restore these functions, however, is often unknown. Here, the authors develop the multiscale interactome, a powerful approach to explain disease treatment.Camilo RuizMarinka ZitnikJure LeskovecNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Camilo Ruiz Marinka Zitnik Jure Leskovec Identification of disease treatment mechanisms through the multiscale interactome
description	Most diseases disrupt multiple proteins, and drugs treat such diseases by restoring the functions of the disrupted proteins; how drugs restore these functions, however, is often unknown. Here, the authors develop the multiscale interactome, a powerful approach to explain disease treatment.
format	article
author	Camilo Ruiz Marinka Zitnik Jure Leskovec
author_facet	Camilo Ruiz Marinka Zitnik Jure Leskovec
author_sort	Camilo Ruiz
title	Identification of disease treatment mechanisms through the multiscale interactome
title_short	Identification of disease treatment mechanisms through the multiscale interactome
title_full	Identification of disease treatment mechanisms through the multiscale interactome
title_fullStr	Identification of disease treatment mechanisms through the multiscale interactome
title_full_unstemmed	Identification of disease treatment mechanisms through the multiscale interactome
title_sort	identification of disease treatment mechanisms through the multiscale interactome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/28f8ca7de94d4f08a6693d3cd37dc25a
work_keys_str_mv	AT camiloruiz identificationofdiseasetreatmentmechanismsthroughthemultiscaleinteractome AT marinkazitnik identificationofdiseasetreatmentmechanismsthroughthemultiscaleinteractome AT jureleskovec identificationofdiseasetreatmentmechanismsthroughthemultiscaleinteractome
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Identification of disease treatment mechanisms through the multiscale interactome

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