Identification of disease treatment mechanisms through the multiscale interactome
Most diseases disrupt multiple proteins, and drugs treat such diseases by restoring the functions of the disrupted proteins; how drugs restore these functions, however, is often unknown. Here, the authors develop the multiscale interactome, a powerful approach to explain disease treatment.
Saved in:
Main Authors: | Camilo Ruiz, Marinka Zitnik, Jure Leskovec |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2021
|
Subjects: | |
Online Access: | https://doaj.org/article/28f8ca7de94d4f08a6693d3cd37dc25a |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Prioritizing network communities
by: Marinka Zitnik, et al.
Published: (2018) -
Network enhancement as a general method to denoise weighted biological networks
by: Bo Wang, et al.
Published: (2018) -
Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease
by: Michael G. Sugiyama, et al.
Published: (2021) -
Leveraging the Cell Ontology to classify unseen cell types
by: Sheng Wang, et al.
Published: (2021) -
Identification and characterization of the BRI2 interactome in the brain
by: Filipa Martins, et al.
Published: (2018)