CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function

Age-related macular degeneration (AMD) has been connected to deficits in autophagy. Here, the authors demonstrate, in mice and dry-AMD patient samples, that calcium and integrin binding protein 2 (CIB2) regulates Rheb-mTORC1 signaling axis, and subsequently autophagy.

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Autores principales:	Saumil Sethna, Patrick A. Scott, Arnaud P. J. Giese, Todd Duncan, Xiaoying Jian, Sheikh Riazuddin, Paul A. Randazzo, T. Michael Redmond, Steven L. Bernstein, Saima Riazuddin, Zubair M. Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/28f9c426a95d413a8bcf70e1675378bc
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spelling	oai:doaj.org-article:28f9c426a95d413a8bcf70e1675378bc2021-12-02T18:02:51ZCIB2 regulates mTORC1 signaling and is essential for autophagy and visual function10.1038/s41467-021-24056-12041-1723https://doaj.org/article/28f9c426a95d413a8bcf70e1675378bc2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24056-1https://doaj.org/toc/2041-1723Age-related macular degeneration (AMD) has been connected to deficits in autophagy. Here, the authors demonstrate, in mice and dry-AMD patient samples, that calcium and integrin binding protein 2 (CIB2) regulates Rheb-mTORC1 signaling axis, and subsequently autophagy.Saumil SethnaPatrick A. ScottArnaud P. J. GieseTodd DuncanXiaoying JianSheikh RiazuddinPaul A. RandazzoT. Michael RedmondSteven L. BernsteinSaima RiazuddinZubair M. AhmedNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Saumil Sethna Patrick A. Scott Arnaud P. J. Giese Todd Duncan Xiaoying Jian Sheikh Riazuddin Paul A. Randazzo T. Michael Redmond Steven L. Bernstein Saima Riazuddin Zubair M. Ahmed CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function
description	Age-related macular degeneration (AMD) has been connected to deficits in autophagy. Here, the authors demonstrate, in mice and dry-AMD patient samples, that calcium and integrin binding protein 2 (CIB2) regulates Rheb-mTORC1 signaling axis, and subsequently autophagy.
format	article
author	Saumil Sethna Patrick A. Scott Arnaud P. J. Giese Todd Duncan Xiaoying Jian Sheikh Riazuddin Paul A. Randazzo T. Michael Redmond Steven L. Bernstein Saima Riazuddin Zubair M. Ahmed
author_facet	Saumil Sethna Patrick A. Scott Arnaud P. J. Giese Todd Duncan Xiaoying Jian Sheikh Riazuddin Paul A. Randazzo T. Michael Redmond Steven L. Bernstein Saima Riazuddin Zubair M. Ahmed
author_sort	Saumil Sethna
title	CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function
title_short	CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function
title_full	CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function
title_fullStr	CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function
title_full_unstemmed	CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function
title_sort	cib2 regulates mtorc1 signaling and is essential for autophagy and visual function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/28f9c426a95d413a8bcf70e1675378bc
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CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function

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