Identification of transmissible proteotoxic oligomer-like fibrils that expand conformational diversity of amyloid assemblies

Nguyen et al identified cytotoxic amyloid fibrils with oligomer-like characteristics, which were assembled from an islet amyloid polypeptide (IAPP) derivative containing an Asn-to-Gln substitution (N21Q). They presented evidence to show that these stable fibrils expand the conformational diversity o...

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Autores principales:	Phuong Trang Nguyen, Ximena Zottig, Mathew Sebastiao, Alexandre A. Arnold, Isabelle Marcotte, Steve Bourgault
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/28feaf14cc72438f8c537516bcfa2027
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spelling	oai:doaj.org-article:28feaf14cc72438f8c537516bcfa20272021-12-02T18:49:23ZIdentification of transmissible proteotoxic oligomer-like fibrils that expand conformational diversity of amyloid assemblies10.1038/s42003-021-02466-72399-3642https://doaj.org/article/28feaf14cc72438f8c537516bcfa20272021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02466-7https://doaj.org/toc/2399-3642Nguyen et al identified cytotoxic amyloid fibrils with oligomer-like characteristics, which were assembled from an islet amyloid polypeptide (IAPP) derivative containing an Asn-to-Gln substitution (N21Q). They presented evidence to show that these stable fibrils expand the conformational diversity of amyloid assemblies, which represents an opportunity to elucidate the structural basis of amyloid disorders.Phuong Trang NguyenXimena ZottigMathew SebastiaoAlexandre A. ArnoldIsabelle MarcotteSteve BourgaultNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Phuong Trang Nguyen Ximena Zottig Mathew Sebastiao Alexandre A. Arnold Isabelle Marcotte Steve Bourgault Identification of transmissible proteotoxic oligomer-like fibrils that expand conformational diversity of amyloid assemblies
description	Nguyen et al identified cytotoxic amyloid fibrils with oligomer-like characteristics, which were assembled from an islet amyloid polypeptide (IAPP) derivative containing an Asn-to-Gln substitution (N21Q). They presented evidence to show that these stable fibrils expand the conformational diversity of amyloid assemblies, which represents an opportunity to elucidate the structural basis of amyloid disorders.
format	article
author	Phuong Trang Nguyen Ximena Zottig Mathew Sebastiao Alexandre A. Arnold Isabelle Marcotte Steve Bourgault
author_facet	Phuong Trang Nguyen Ximena Zottig Mathew Sebastiao Alexandre A. Arnold Isabelle Marcotte Steve Bourgault
author_sort	Phuong Trang Nguyen
title	Identification of transmissible proteotoxic oligomer-like fibrils that expand conformational diversity of amyloid assemblies
title_short	Identification of transmissible proteotoxic oligomer-like fibrils that expand conformational diversity of amyloid assemblies
title_full	Identification of transmissible proteotoxic oligomer-like fibrils that expand conformational diversity of amyloid assemblies
title_fullStr	Identification of transmissible proteotoxic oligomer-like fibrils that expand conformational diversity of amyloid assemblies
title_full_unstemmed	Identification of transmissible proteotoxic oligomer-like fibrils that expand conformational diversity of amyloid assemblies
title_sort	identification of transmissible proteotoxic oligomer-like fibrils that expand conformational diversity of amyloid assemblies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/28feaf14cc72438f8c537516bcfa2027
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Identification of transmissible proteotoxic oligomer-like fibrils that expand conformational diversity of amyloid assemblies

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