Identification of transmissible proteotoxic oligomer-like fibrils that expand conformational diversity of amyloid assemblies

Nguyen et al identified cytotoxic amyloid fibrils with oligomer-like characteristics, which were assembled from an islet amyloid polypeptide (IAPP) derivative containing an Asn-to-Gln substitution (N21Q). They presented evidence to show that these stable fibrils expand the conformational diversity o...

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Autores principales: Phuong Trang Nguyen, Ximena Zottig, Mathew Sebastiao, Alexandre A. Arnold, Isabelle Marcotte, Steve Bourgault
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/28feaf14cc72438f8c537516bcfa2027
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