Cardiac troponin I and the risk of cardiovascular or non-cardiovascular death in patients visiting the emergency department

Abstract The prognostic implication of cardiac troponin I (cTnI) values for the determination of the magnitude or duration of cause-specific death risk is limited. We included consecutive patients with maximal cTnI values within 24 h of their emergency department visits. Multivariate analyses using...

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Autores principales:	Jong Eun Park, Minseok Song, Taerim Kim, Gun Tak Lee, Sung Yeon Hwang, Hee Yoon, Won Chul Cha, Tae Gun Shin, Min Sub Sim, Ik Joon Jo, Seung-Hwa Lee, Hyung-Doo Park, Jin-Ho Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/28fef70f7a1b4b299e40a72488d37434
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spelling	oai:doaj.org-article:28fef70f7a1b4b299e40a72488d374342021-12-02T15:28:57ZCardiac troponin I and the risk of cardiovascular or non-cardiovascular death in patients visiting the emergency department10.1038/s41598-021-96951-y2045-2322https://doaj.org/article/28fef70f7a1b4b299e40a72488d374342021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96951-yhttps://doaj.org/toc/2045-2322Abstract The prognostic implication of cardiac troponin I (cTnI) values for the determination of the magnitude or duration of cause-specific death risk is limited. We included consecutive patients with maximal cTnI values within 24 h of their emergency department visits. Multivariate analyses using variables selected by the Bayesian information criterion were performed to investigate the impact of cTnI on the event rate, time-dependent risk, and dose-dependent risk of cardiovascular or non-cardiovascular death within 360 days. There were 5472 (14.9%) all-cause deaths including 881 (2.4%) cardiovascular deaths and 4591 (12.5%) non-cardiovascular deaths. In patients with positive cTnI, defined as the ≥ 99th percentile of the upper normal limit, the cumulative risk of cardiac and non-cardiac death was 4.4- and 1.4-fold higher, respectively, than that of negative cTnI, respectively. In the competing risk analysis, positive cTnI was linked to 2.4- and 1.2-fold higher risks of cardiovascular and non-cardiovascular death, respectively. The cTnI value showed a positive relationship with the risk of both cardiovascular and non-cardiovascular deaths. In the time-dependent risk analysis, the excess risk of cardiovascular death was mostly evident in the first few weeks. Higher cTnI value was associated with an increased risk of both cardiovascular and non-cardiovascular death, especially which was in the early period.Jong Eun ParkMinseok SongTaerim KimGun Tak LeeSung Yeon HwangHee YoonWon Chul ChaTae Gun ShinMin Sub SimIk Joon JoSeung-Hwa LeeHyung-Doo ParkJin-Ho ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jong Eun Park Minseok Song Taerim Kim Gun Tak Lee Sung Yeon Hwang Hee Yoon Won Chul Cha Tae Gun Shin Min Sub Sim Ik Joon Jo Seung-Hwa Lee Hyung-Doo Park Jin-Ho Choi Cardiac troponin I and the risk of cardiovascular or non-cardiovascular death in patients visiting the emergency department
description	Abstract The prognostic implication of cardiac troponin I (cTnI) values for the determination of the magnitude or duration of cause-specific death risk is limited. We included consecutive patients with maximal cTnI values within 24 h of their emergency department visits. Multivariate analyses using variables selected by the Bayesian information criterion were performed to investigate the impact of cTnI on the event rate, time-dependent risk, and dose-dependent risk of cardiovascular or non-cardiovascular death within 360 days. There were 5472 (14.9%) all-cause deaths including 881 (2.4%) cardiovascular deaths and 4591 (12.5%) non-cardiovascular deaths. In patients with positive cTnI, defined as the ≥ 99th percentile of the upper normal limit, the cumulative risk of cardiac and non-cardiac death was 4.4- and 1.4-fold higher, respectively, than that of negative cTnI, respectively. In the competing risk analysis, positive cTnI was linked to 2.4- and 1.2-fold higher risks of cardiovascular and non-cardiovascular death, respectively. The cTnI value showed a positive relationship with the risk of both cardiovascular and non-cardiovascular deaths. In the time-dependent risk analysis, the excess risk of cardiovascular death was mostly evident in the first few weeks. Higher cTnI value was associated with an increased risk of both cardiovascular and non-cardiovascular death, especially which was in the early period.
format	article
author	Jong Eun Park Minseok Song Taerim Kim Gun Tak Lee Sung Yeon Hwang Hee Yoon Won Chul Cha Tae Gun Shin Min Sub Sim Ik Joon Jo Seung-Hwa Lee Hyung-Doo Park Jin-Ho Choi
author_facet	Jong Eun Park Minseok Song Taerim Kim Gun Tak Lee Sung Yeon Hwang Hee Yoon Won Chul Cha Tae Gun Shin Min Sub Sim Ik Joon Jo Seung-Hwa Lee Hyung-Doo Park Jin-Ho Choi
author_sort	Jong Eun Park
title	Cardiac troponin I and the risk of cardiovascular or non-cardiovascular death in patients visiting the emergency department
title_short	Cardiac troponin I and the risk of cardiovascular or non-cardiovascular death in patients visiting the emergency department
title_full	Cardiac troponin I and the risk of cardiovascular or non-cardiovascular death in patients visiting the emergency department
title_fullStr	Cardiac troponin I and the risk of cardiovascular or non-cardiovascular death in patients visiting the emergency department
title_full_unstemmed	Cardiac troponin I and the risk of cardiovascular or non-cardiovascular death in patients visiting the emergency department
title_sort	cardiac troponin i and the risk of cardiovascular or non-cardiovascular death in patients visiting the emergency department
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/28fef70f7a1b4b299e40a72488d37434
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Cardiac troponin I and the risk of cardiovascular or non-cardiovascular death in patients visiting the emergency department

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