The Role of miR-23b in Cancer and Autoimmune Disease
Short-stranded miRNAs are single-stranded RNA molecules involved in the regulation of gene expression. miRNAs are involved in a variety of cellular physiological processes, including cell proliferation, differentiation, and apoptosis. miR-23b have been identified to act both as oncogenes and as tumo...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Hindawi Limited
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/2900c072723344f299ea698ac808dd89 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:2900c072723344f299ea698ac808dd89 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:2900c072723344f299ea698ac808dd892021-11-15T01:19:06ZThe Role of miR-23b in Cancer and Autoimmune Disease1687-846910.1155/2021/6473038https://doaj.org/article/2900c072723344f299ea698ac808dd892021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/6473038https://doaj.org/toc/1687-8469Short-stranded miRNAs are single-stranded RNA molecules involved in the regulation of gene expression. miRNAs are involved in a variety of cellular physiological processes, including cell proliferation, differentiation, and apoptosis. miR-23b have been identified to act both as oncogenes and as tumor suppressors. In addition, miR-23b is related to inflammation resistance to various autoimmune diseases and restrained inflammatory cell migration. The characterization of the specific alterations in the patterns of miR-23b expression in cancer and autoimmune disease has great potential for identifying biomarkers for early disease diagnosis, as well as for potential therapeutic intervention in various diseases. In this review, we summarize the ever-expanding role of miR-23b and its target genes in different models and offer insight into how this multifunctional miRNA modulates tumor cell proliferation and apoptosis or inflammatory cell activation, differentiation, and migration.Yu-Xin GuoNa WangWen-Cheng WuCui-Qin LiRui-Heng ChenYuan ZhangXing LiHindawi LimitedarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of Oncology, Vol 2021 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yu-Xin Guo Na Wang Wen-Cheng Wu Cui-Qin Li Rui-Heng Chen Yuan Zhang Xing Li The Role of miR-23b in Cancer and Autoimmune Disease |
| description |
Short-stranded miRNAs are single-stranded RNA molecules involved in the regulation of gene expression. miRNAs are involved in a variety of cellular physiological processes, including cell proliferation, differentiation, and apoptosis. miR-23b have been identified to act both as oncogenes and as tumor suppressors. In addition, miR-23b is related to inflammation resistance to various autoimmune diseases and restrained inflammatory cell migration. The characterization of the specific alterations in the patterns of miR-23b expression in cancer and autoimmune disease has great potential for identifying biomarkers for early disease diagnosis, as well as for potential therapeutic intervention in various diseases. In this review, we summarize the ever-expanding role of miR-23b and its target genes in different models and offer insight into how this multifunctional miRNA modulates tumor cell proliferation and apoptosis or inflammatory cell activation, differentiation, and migration. |
| format |
article |
| author |
Yu-Xin Guo Na Wang Wen-Cheng Wu Cui-Qin Li Rui-Heng Chen Yuan Zhang Xing Li |
| author_facet |
Yu-Xin Guo Na Wang Wen-Cheng Wu Cui-Qin Li Rui-Heng Chen Yuan Zhang Xing Li |
| author_sort |
Yu-Xin Guo |
| title |
The Role of miR-23b in Cancer and Autoimmune Disease |
| title_short |
The Role of miR-23b in Cancer and Autoimmune Disease |
| title_full |
The Role of miR-23b in Cancer and Autoimmune Disease |
| title_fullStr |
The Role of miR-23b in Cancer and Autoimmune Disease |
| title_full_unstemmed |
The Role of miR-23b in Cancer and Autoimmune Disease |
| title_sort |
role of mir-23b in cancer and autoimmune disease |
| publisher |
Hindawi Limited |
| publishDate |
2021 |
| url |
https://doaj.org/article/2900c072723344f299ea698ac808dd89 |
| work_keys_str_mv |
AT yuxinguo theroleofmir23bincancerandautoimmunedisease AT nawang theroleofmir23bincancerandautoimmunedisease AT wenchengwu theroleofmir23bincancerandautoimmunedisease AT cuiqinli theroleofmir23bincancerandautoimmunedisease AT ruihengchen theroleofmir23bincancerandautoimmunedisease AT yuanzhang theroleofmir23bincancerandautoimmunedisease AT xingli theroleofmir23bincancerandautoimmunedisease AT yuxinguo roleofmir23bincancerandautoimmunedisease AT nawang roleofmir23bincancerandautoimmunedisease AT wenchengwu roleofmir23bincancerandautoimmunedisease AT cuiqinli roleofmir23bincancerandautoimmunedisease AT ruihengchen roleofmir23bincancerandautoimmunedisease AT yuanzhang roleofmir23bincancerandautoimmunedisease AT xingli roleofmir23bincancerandautoimmunedisease |
| _version_ |
1718428970753458176 |