Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease—A Polish Population-Based Study

Deleted in malignant brain tumours 1 protein (DMBT1) and surfactant protein D (SFTPD) are antimicrobial peptides previously linked to inflammatory bowel disease (IBD) susceptibility. This study attempts to link the most potential IBD-associated polymorphisms in DMBT1 and SFTPD with the disease sever...

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Autores principales:	Aleksandra Glapa-Nowak, Mariusz Szczepanik, Aleksandra Banaszkiewicz, Barbara Iwańczak, Jarosław Kwiecień, Anna Szaflarska-Popławska, Urszula Grzybowska-Chlebowczyk, Marcin Osiecki, Jarosław Kierkuś, Marcin Banasiuk, Tomasz Banasiewicz, Jens Madsen, Jarosław Walkowiak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Crohn’s disease exacerbation hospitalisation immunosuppression ulcerative colitis polymorphism Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/290413af9d00408a85fd12502580e466
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spelling	oai:doaj.org-article:290413af9d00408a85fd12502580e4662021-11-25T17:13:48ZGenetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease—A Polish Population-Based Study10.3390/children81109462227-9067https://doaj.org/article/290413af9d00408a85fd12502580e4662021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9067/8/11/946https://doaj.org/toc/2227-9067Deleted in malignant brain tumours 1 protein (DMBT1) and surfactant protein D (SFTPD) are antimicrobial peptides previously linked to inflammatory bowel disease (IBD) susceptibility. This study attempts to link the most potential IBD-associated polymorphisms in DMBT1 and SFTPD with the disease severity in children. A total of 406 IBD patients (Crohn’s disease (CD) <i>n</i> = 214 and ulcerative colitis (UC) <i>n</i> = 192) were genotyped using hydrolysis probe assay. Clinical expression was described by disease activity scales, albumin and C-reactive protein levels, localisation and behaviour (Paris classification), systemic steroid, immunosuppressive, biological, and surgical treatment, number of exacerbation-caused hospitalisations, relapses and nutritional status. IBD patients with the risk genotype (AA) in DMBT1 rs2981804 had more frequent biological treatment (AA: vs. AG/GG; <i>p</i> = 0.012), concomitant diseases (AA vs. AG vs. GG; <i>p</i> = 0.015) and cutaneous manifestations (AA vs. AG/GG, <i>p</i> = 0.008). In UC, rs2981804 genotypes might be linked with albumin concentrations at diagnosis (AA vs. AG vs. GG; <i>p</i> = 0.009). In CD, DMBT1 rs2981745 was significantly associated with the number of severe relapses per year of disease (<i>p</i> = 0.020) and time-to-immunosuppression (<i>p</i> = 0.045). SFTPD was seemingly found to be associated with age at first immunosuppression in IBD (CC vs. CT vs. TT; <i>p</i> = 0.048). In conclusion, selected polymorphisms of DMBT1 and SFTPD might be associated with some disease severity measures in children with IBD. However, the magnitude of associations and their clinical relevance might be minor.Aleksandra Glapa-NowakMariusz SzczepanikAleksandra BanaszkiewiczBarbara IwańczakJarosław KwiecieńAnna Szaflarska-PopławskaUrszula Grzybowska-ChlebowczykMarcin OsieckiJarosław KierkuśMarcin BanasiukTomasz BanasiewiczJens MadsenJarosław WalkowiakMDPI AGarticleCrohn’s diseaseexacerbationhospitalisationimmunosuppressionulcerative colitispolymorphismPediatricsRJ1-570ENChildren, Vol 8, Iss 946, p 946 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Crohn’s disease exacerbation hospitalisation immunosuppression ulcerative colitis polymorphism Pediatrics RJ1-570
spellingShingle	Crohn’s disease exacerbation hospitalisation immunosuppression ulcerative colitis polymorphism Pediatrics RJ1-570 Aleksandra Glapa-Nowak Mariusz Szczepanik Aleksandra Banaszkiewicz Barbara Iwańczak Jarosław Kwiecień Anna Szaflarska-Popławska Urszula Grzybowska-Chlebowczyk Marcin Osiecki Jarosław Kierkuś Marcin Banasiuk Tomasz Banasiewicz Jens Madsen Jarosław Walkowiak Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease—A Polish Population-Based Study
description	Deleted in malignant brain tumours 1 protein (DMBT1) and surfactant protein D (SFTPD) are antimicrobial peptides previously linked to inflammatory bowel disease (IBD) susceptibility. This study attempts to link the most potential IBD-associated polymorphisms in DMBT1 and SFTPD with the disease severity in children. A total of 406 IBD patients (Crohn’s disease (CD) <i>n</i> = 214 and ulcerative colitis (UC) <i>n</i> = 192) were genotyped using hydrolysis probe assay. Clinical expression was described by disease activity scales, albumin and C-reactive protein levels, localisation and behaviour (Paris classification), systemic steroid, immunosuppressive, biological, and surgical treatment, number of exacerbation-caused hospitalisations, relapses and nutritional status. IBD patients with the risk genotype (AA) in DMBT1 rs2981804 had more frequent biological treatment (AA: vs. AG/GG; <i>p</i> = 0.012), concomitant diseases (AA vs. AG vs. GG; <i>p</i> = 0.015) and cutaneous manifestations (AA vs. AG/GG, <i>p</i> = 0.008). In UC, rs2981804 genotypes might be linked with albumin concentrations at diagnosis (AA vs. AG vs. GG; <i>p</i> = 0.009). In CD, DMBT1 rs2981745 was significantly associated with the number of severe relapses per year of disease (<i>p</i> = 0.020) and time-to-immunosuppression (<i>p</i> = 0.045). SFTPD was seemingly found to be associated with age at first immunosuppression in IBD (CC vs. CT vs. TT; <i>p</i> = 0.048). In conclusion, selected polymorphisms of DMBT1 and SFTPD might be associated with some disease severity measures in children with IBD. However, the magnitude of associations and their clinical relevance might be minor.
format	article
author	Aleksandra Glapa-Nowak Mariusz Szczepanik Aleksandra Banaszkiewicz Barbara Iwańczak Jarosław Kwiecień Anna Szaflarska-Popławska Urszula Grzybowska-Chlebowczyk Marcin Osiecki Jarosław Kierkuś Marcin Banasiuk Tomasz Banasiewicz Jens Madsen Jarosław Walkowiak
author_facet	Aleksandra Glapa-Nowak Mariusz Szczepanik Aleksandra Banaszkiewicz Barbara Iwańczak Jarosław Kwiecień Anna Szaflarska-Popławska Urszula Grzybowska-Chlebowczyk Marcin Osiecki Jarosław Kierkuś Marcin Banasiuk Tomasz Banasiewicz Jens Madsen Jarosław Walkowiak
author_sort	Aleksandra Glapa-Nowak
title	Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease—A Polish Population-Based Study
title_short	Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease—A Polish Population-Based Study
title_full	Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease—A Polish Population-Based Study
title_fullStr	Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease—A Polish Population-Based Study
title_full_unstemmed	Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease—A Polish Population-Based Study
title_sort	genetic variants of dmbt1 and sftpd and disease severity in paediatric inflammatory bowel disease—a polish population-based study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/290413af9d00408a85fd12502580e466
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Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease—A Polish Population-Based Study

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