Memory of cell shape biases stochastic fate decision-making despite mitotic rounding

Cell shape influences function but during mitotic cell rounding the original shape is lost. Here the authors show that the cellular eccentricity of progenitor cell biases stochastic fate-decisions using a combination of quantitative live imaging, genetic manipulations and computational simulations.

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Autores principales:	Takashi Akanuma, Cong Chen, Tetsuo Sato, Roeland M. H. Merks, Thomas N. Sato
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2908ae23dcda49d393c0efb4eba5f0ce
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spelling	oai:doaj.org-article:2908ae23dcda49d393c0efb4eba5f0ce2021-12-02T14:38:33ZMemory of cell shape biases stochastic fate decision-making despite mitotic rounding10.1038/ncomms119632041-1723https://doaj.org/article/2908ae23dcda49d393c0efb4eba5f0ce2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11963https://doaj.org/toc/2041-1723Cell shape influences function but during mitotic cell rounding the original shape is lost. Here the authors show that the cellular eccentricity of progenitor cell biases stochastic fate-decisions using a combination of quantitative live imaging, genetic manipulations and computational simulations.Takashi AkanumaCong ChenTetsuo SatoRoeland M. H. MerksThomas N. SatoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takashi Akanuma Cong Chen Tetsuo Sato Roeland M. H. Merks Thomas N. Sato Memory of cell shape biases stochastic fate decision-making despite mitotic rounding
description	Cell shape influences function but during mitotic cell rounding the original shape is lost. Here the authors show that the cellular eccentricity of progenitor cell biases stochastic fate-decisions using a combination of quantitative live imaging, genetic manipulations and computational simulations.
format	article
author	Takashi Akanuma Cong Chen Tetsuo Sato Roeland M. H. Merks Thomas N. Sato
author_facet	Takashi Akanuma Cong Chen Tetsuo Sato Roeland M. H. Merks Thomas N. Sato
author_sort	Takashi Akanuma
title	Memory of cell shape biases stochastic fate decision-making despite mitotic rounding
title_short	Memory of cell shape biases stochastic fate decision-making despite mitotic rounding
title_full	Memory of cell shape biases stochastic fate decision-making despite mitotic rounding
title_fullStr	Memory of cell shape biases stochastic fate decision-making despite mitotic rounding
title_full_unstemmed	Memory of cell shape biases stochastic fate decision-making despite mitotic rounding
title_sort	memory of cell shape biases stochastic fate decision-making despite mitotic rounding
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2908ae23dcda49d393c0efb4eba5f0ce
work_keys_str_mv	AT takashiakanuma memoryofcellshapebiasesstochasticfatedecisionmakingdespitemitoticrounding AT congchen memoryofcellshapebiasesstochasticfatedecisionmakingdespitemitoticrounding AT tetsuosato memoryofcellshapebiasesstochasticfatedecisionmakingdespitemitoticrounding AT roelandmhmerks memoryofcellshapebiasesstochasticfatedecisionmakingdespitemitoticrounding AT thomasnsato memoryofcellshapebiasesstochasticfatedecisionmakingdespitemitoticrounding
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Memory of cell shape biases stochastic fate decision-making despite mitotic rounding

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