Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells

Back-propagating action potentials (bAP) and NMDA dendritic spikes have both been linked to long-term plasticity (LTP) induction, though it is unclear which factors are essential. Here, using electrophysiology and Ca2+imaging, the authors find NMDA spikes are a key initiator of LTP, and that bAP con...

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Autores principales:	Federico Brandalise, Stefano Carta, Fritjof Helmchen, John Lisman, Urs Gerber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2908b943bc3c4225a0c309827bec226c
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spelling	oai:doaj.org-article:2908b943bc3c4225a0c309827bec226c2021-12-02T14:40:14ZDendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells10.1038/ncomms134802041-1723https://doaj.org/article/2908b943bc3c4225a0c309827bec226c2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13480https://doaj.org/toc/2041-1723Back-propagating action potentials (bAP) and NMDA dendritic spikes have both been linked to long-term plasticity (LTP) induction, though it is unclear which factors are essential. Here, using electrophysiology and Ca2+imaging, the authors find NMDA spikes are a key initiator of LTP, and that bAP contribution occurs via NMDA spike triggering.Federico BrandaliseStefano CartaFritjof HelmchenJohn LismanUrs GerberNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Federico Brandalise Stefano Carta Fritjof Helmchen John Lisman Urs Gerber Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells
description	Back-propagating action potentials (bAP) and NMDA dendritic spikes have both been linked to long-term plasticity (LTP) induction, though it is unclear which factors are essential. Here, using electrophysiology and Ca2+imaging, the authors find NMDA spikes are a key initiator of LTP, and that bAP contribution occurs via NMDA spike triggering.
format	article
author	Federico Brandalise Stefano Carta Fritjof Helmchen John Lisman Urs Gerber
author_facet	Federico Brandalise Stefano Carta Fritjof Helmchen John Lisman Urs Gerber
author_sort	Federico Brandalise
title	Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells
title_short	Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells
title_full	Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells
title_fullStr	Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells
title_full_unstemmed	Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells
title_sort	dendritic nmda spikes are necessary for timing-dependent associative ltp in ca3 pyramidal cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2908b943bc3c4225a0c309827bec226c
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Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells

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