Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells

Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells

Back-propagating action potentials (bAP) and NMDA dendritic spikes have both been linked to long-term plasticity (LTP) induction, though it is unclear which factors are essential. Here, using electrophysiology and Ca2+imaging, the authors find NMDA spikes are a key initiator of LTP, and that bAP con...

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Autores principales: Federico Brandalise, Stefano Carta, Fritjof Helmchen, John Lisman, Urs Gerber
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/2908b943bc3c4225a0c309827bec226c
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