The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity
The ion channel TRPV4 senses many environmental cues, but its role in virus infection is not known. Here, Doñate-Macián et al. show that Zika virus induces TRPV4-mediated Ca2+ influx into cells, resulting in the nuclear accumulation of the DDX3X RNA helicase, which increases virus replication.
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Nature Portfolio
2018
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oai:doaj.org-article:290d676b0dbd42a9b8c7723087182bad2021-12-02T16:49:20ZThe TRPV4 channel links calcium influx to DDX3X activity and viral infectivity10.1038/s41467-018-04776-72041-1723https://doaj.org/article/290d676b0dbd42a9b8c7723087182bad2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04776-7https://doaj.org/toc/2041-1723The ion channel TRPV4 senses many environmental cues, but its role in virus infection is not known. Here, Doñate-Macián et al. show that Zika virus induces TRPV4-mediated Ca2+ influx into cells, resulting in the nuclear accumulation of the DDX3X RNA helicase, which increases virus replication.P. Doñate-MaciánJ. JungfleischG. Pérez-VilaróF. Rubio-MoscardoA. Perálvarez-MarínJ. DiezM. A. ValverdeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q P. Doñate-Macián J. Jungfleisch G. Pérez-Vilaró F. Rubio-Moscardo A. Perálvarez-Marín J. Diez M. A. Valverde The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity |
| description |
The ion channel TRPV4 senses many environmental cues, but its role in virus infection is not known. Here, Doñate-Macián et al. show that Zika virus induces TRPV4-mediated Ca2+ influx into cells, resulting in the nuclear accumulation of the DDX3X RNA helicase, which increases virus replication. |
| format |
article |
| author |
P. Doñate-Macián J. Jungfleisch G. Pérez-Vilaró F. Rubio-Moscardo A. Perálvarez-Marín J. Diez M. A. Valverde |
| author_facet |
P. Doñate-Macián J. Jungfleisch G. Pérez-Vilaró F. Rubio-Moscardo A. Perálvarez-Marín J. Diez M. A. Valverde |
| author_sort |
P. Doñate-Macián |
| title |
The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity |
| title_short |
The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity |
| title_full |
The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity |
| title_fullStr |
The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity |
| title_full_unstemmed |
The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity |
| title_sort |
trpv4 channel links calcium influx to ddx3x activity and viral infectivity |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/290d676b0dbd42a9b8c7723087182bad |
| work_keys_str_mv |
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