The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity
The ion channel TRPV4 senses many environmental cues, but its role in virus infection is not known. Here, Doñate-Macián et al. show that Zika virus induces TRPV4-mediated Ca2+ influx into cells, resulting in the nuclear accumulation of the DDX3X RNA helicase, which increases virus replication.
Guardado en:
Autores principales: | P. Doñate-Macián, J. Jungfleisch, G. Pérez-Vilaró, F. Rubio-Moscardo, A. Perálvarez-Marín, J. Diez, M. A. Valverde |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/290d676b0dbd42a9b8c7723087182bad |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Swapping of transmembrane domains in the epithelial calcium channel TRPV6
por: Appu K. Singh, et al.
Publicado: (2017) -
Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment
por: Kyun-Do Kim, et al.
Publicado: (2017) -
Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5.
por: Nellie Y Loh, et al.
Publicado: (2013) -
Crbn modulates calcium influx by regulating Orai1 during efferocytosis
por: Hyunji Moon, et al.
Publicado: (2020) -
Conformational ensemble of the human TRPV3 ion channel
por: Lejla Zubcevic, et al.
Publicado: (2018)