Unrepaired decompressive craniectomy worsens motor performance in a rat traumatic brain injury model

Abstract Decompressive craniectomy (DC) is often required to manage rising intracranial pressure after traumatic brain injury (TBI). Syndrome of the trephine (SoT) is a reversible neurologic condition that often occurs following DC as a result of the unrepaired skull. The purpose of the present stud...

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Autores principales:	Brian T. Andrews, Scott Barbay, Jakob Townsend, Michael Detamore, Janna Harris, Chad Tuchek, Randolph J. Nudo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/290fcab1e5a1432998e331f64a3367c9
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spelling	oai:doaj.org-article:290fcab1e5a1432998e331f64a3367c92021-12-02T13:34:00ZUnrepaired decompressive craniectomy worsens motor performance in a rat traumatic brain injury model10.1038/s41598-020-79155-82045-2322https://doaj.org/article/290fcab1e5a1432998e331f64a3367c92020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79155-8https://doaj.org/toc/2045-2322Abstract Decompressive craniectomy (DC) is often required to manage rising intracranial pressure after traumatic brain injury (TBI). Syndrome of the trephine (SoT) is a reversible neurologic condition that often occurs following DC as a result of the unrepaired skull. The purpose of the present study is to characterize neurological impairment following TBI in rats with an unrepaired craniectomy versus rats with a closed cranium. Long Evans male rats received a controlled cortical impact (CCI) over the caudal forelimb area (CFA) of the motor cortex. Immediately after CCI, rats received either a hemi-craniectomy (TBI Open Skull Group) or an immediate acrylic cranioplasty restoring cranial anatomy (TBI Closed Skull Group). Motor performance was assessed on a skilled reaching task on post-CCI weeks 1—4, 8, 12, and 16. Three weeks after the CCI injury, the TBI Closed Skull Group demonstrated improved motor performance compared to TBI Open Skull Group. The TBI Closed Skull Group continued to perform better than the TBI Open Skull Group throughout weeks 4, 8, 12 and 16. The protracted recovery of CFA motor performance demonstrated in rats with unrepaired skulls following TBI suggests this model may be beneficial for testing new therapeutic approaches to prevent SoT.Brian T. AndrewsScott BarbayJakob TownsendMichael DetamoreJanna HarrisChad TuchekRandolph J. NudoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Brian T. Andrews Scott Barbay Jakob Townsend Michael Detamore Janna Harris Chad Tuchek Randolph J. Nudo Unrepaired decompressive craniectomy worsens motor performance in a rat traumatic brain injury model
description	Abstract Decompressive craniectomy (DC) is often required to manage rising intracranial pressure after traumatic brain injury (TBI). Syndrome of the trephine (SoT) is a reversible neurologic condition that often occurs following DC as a result of the unrepaired skull. The purpose of the present study is to characterize neurological impairment following TBI in rats with an unrepaired craniectomy versus rats with a closed cranium. Long Evans male rats received a controlled cortical impact (CCI) over the caudal forelimb area (CFA) of the motor cortex. Immediately after CCI, rats received either a hemi-craniectomy (TBI Open Skull Group) or an immediate acrylic cranioplasty restoring cranial anatomy (TBI Closed Skull Group). Motor performance was assessed on a skilled reaching task on post-CCI weeks 1—4, 8, 12, and 16. Three weeks after the CCI injury, the TBI Closed Skull Group demonstrated improved motor performance compared to TBI Open Skull Group. The TBI Closed Skull Group continued to perform better than the TBI Open Skull Group throughout weeks 4, 8, 12 and 16. The protracted recovery of CFA motor performance demonstrated in rats with unrepaired skulls following TBI suggests this model may be beneficial for testing new therapeutic approaches to prevent SoT.
format	article
author	Brian T. Andrews Scott Barbay Jakob Townsend Michael Detamore Janna Harris Chad Tuchek Randolph J. Nudo
author_facet	Brian T. Andrews Scott Barbay Jakob Townsend Michael Detamore Janna Harris Chad Tuchek Randolph J. Nudo
author_sort	Brian T. Andrews
title	Unrepaired decompressive craniectomy worsens motor performance in a rat traumatic brain injury model
title_short	Unrepaired decompressive craniectomy worsens motor performance in a rat traumatic brain injury model
title_full	Unrepaired decompressive craniectomy worsens motor performance in a rat traumatic brain injury model
title_fullStr	Unrepaired decompressive craniectomy worsens motor performance in a rat traumatic brain injury model
title_full_unstemmed	Unrepaired decompressive craniectomy worsens motor performance in a rat traumatic brain injury model
title_sort	unrepaired decompressive craniectomy worsens motor performance in a rat traumatic brain injury model
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/290fcab1e5a1432998e331f64a3367c9
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Unrepaired decompressive craniectomy worsens motor performance in a rat traumatic brain injury model

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