A heparan-dependent herpesvirus targets the olfactory neuroepithelium for host entry.

Herpesviruses are ubiquitous pathogens that cause much disease. The difficulty of clearing their established infections makes host entry an important target for control. However, while herpesviruses have been studied extensively in vitro, how they cross differentiated mucus-covered epithelia in vivo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ricardo Milho, Bruno Frederico, Stacey Efstathiou, Philip G Stevenson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/29114560fee647d8bb1fbaec920b9f79
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:29114560fee647d8bb1fbaec920b9f79
record_format	dspace
spelling	oai:doaj.org-article:29114560fee647d8bb1fbaec920b9f792021-11-18T06:06:25ZA heparan-dependent herpesvirus targets the olfactory neuroepithelium for host entry.1553-73661553-737410.1371/journal.ppat.1002986https://doaj.org/article/29114560fee647d8bb1fbaec920b9f792012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23133384/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Herpesviruses are ubiquitous pathogens that cause much disease. The difficulty of clearing their established infections makes host entry an important target for control. However, while herpesviruses have been studied extensively in vitro, how they cross differentiated mucus-covered epithelia in vivo is unclear. To establish general principles we tracked host entry by Murid Herpesvirus-4 (MuHV-4), a lymphotropic rhadinovirus related to the Kaposi's Sarcoma-associated Herpesvirus. Spontaneously acquired virions targeted the olfactory neuroepithelium. Like many herpesviruses, MuHV-4 binds to heparan sulfate (HS), and virions unable to bind HS showed poor host entry. While the respiratory epithelium expressed only basolateral HS and was bound poorly by incoming virions, the neuroepithelium also displayed HS on its apical neuronal cilia and was bound strongly. Incoming virions tracked down the neuronal cilia, and either infected neurons or reached the underlying microvilli of the adjacent glial (sustentacular) cells and infected them. Thus the olfactory neuroepithelium provides an important and complex site of HS-dependent herpesvirus uptake.Ricardo MilhoBruno FredericoStacey EfstathiouPhilip G StevensonPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 8, Iss 11, p e1002986 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Ricardo Milho Bruno Frederico Stacey Efstathiou Philip G Stevenson A heparan-dependent herpesvirus targets the olfactory neuroepithelium for host entry.
description	Herpesviruses are ubiquitous pathogens that cause much disease. The difficulty of clearing their established infections makes host entry an important target for control. However, while herpesviruses have been studied extensively in vitro, how they cross differentiated mucus-covered epithelia in vivo is unclear. To establish general principles we tracked host entry by Murid Herpesvirus-4 (MuHV-4), a lymphotropic rhadinovirus related to the Kaposi's Sarcoma-associated Herpesvirus. Spontaneously acquired virions targeted the olfactory neuroepithelium. Like many herpesviruses, MuHV-4 binds to heparan sulfate (HS), and virions unable to bind HS showed poor host entry. While the respiratory epithelium expressed only basolateral HS and was bound poorly by incoming virions, the neuroepithelium also displayed HS on its apical neuronal cilia and was bound strongly. Incoming virions tracked down the neuronal cilia, and either infected neurons or reached the underlying microvilli of the adjacent glial (sustentacular) cells and infected them. Thus the olfactory neuroepithelium provides an important and complex site of HS-dependent herpesvirus uptake.
format	article
author	Ricardo Milho Bruno Frederico Stacey Efstathiou Philip G Stevenson
author_facet	Ricardo Milho Bruno Frederico Stacey Efstathiou Philip G Stevenson
author_sort	Ricardo Milho
title	A heparan-dependent herpesvirus targets the olfactory neuroepithelium for host entry.
title_short	A heparan-dependent herpesvirus targets the olfactory neuroepithelium for host entry.
title_full	A heparan-dependent herpesvirus targets the olfactory neuroepithelium for host entry.
title_fullStr	A heparan-dependent herpesvirus targets the olfactory neuroepithelium for host entry.
title_full_unstemmed	A heparan-dependent herpesvirus targets the olfactory neuroepithelium for host entry.
title_sort	heparan-dependent herpesvirus targets the olfactory neuroepithelium for host entry.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/29114560fee647d8bb1fbaec920b9f79
work_keys_str_mv	AT ricardomilho aheparandependentherpesvirustargetstheolfactoryneuroepitheliumforhostentry AT brunofrederico aheparandependentherpesvirustargetstheolfactoryneuroepitheliumforhostentry AT staceyefstathiou aheparandependentherpesvirustargetstheolfactoryneuroepitheliumforhostentry AT philipgstevenson aheparandependentherpesvirustargetstheolfactoryneuroepitheliumforhostentry AT ricardomilho heparandependentherpesvirustargetstheolfactoryneuroepitheliumforhostentry AT brunofrederico heparandependentherpesvirustargetstheolfactoryneuroepitheliumforhostentry AT staceyefstathiou heparandependentherpesvirustargetstheolfactoryneuroepitheliumforhostentry AT philipgstevenson heparandependentherpesvirustargetstheolfactoryneuroepitheliumforhostentry
_version_	1718424525221134336

A heparan-dependent herpesvirus targets the olfactory neuroepithelium for host entry.

Ejemplares similares