A fluorescent protein scaffold for presenting structurally constrained peptides provides an effective screening system to identify high affinity target-binding peptides.

A fluorescent protein scaffold for presenting structurally constrained peptides provides an effective screening system to identify high affinity target-binding peptides.

Peptides that have high affinity for target molecules on the surface of cancer cells are crucial for the development of targeted cancer therapies. However, unstructured peptides often fail to bind their target molecules with high affinity. To efficiently identify high-affinity target-binding peptide...

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Autores principales: Tetsuya Kadonosono, Etsuri Yabe, Tadaomi Furuta, Akihiro Yamano, Takuya Tsubaki, Takuya Sekine, Takahiro Kuchimaru, Minoru Sakurai, Shinae Kizaka-Kondoh
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/29142f9390054aa7838d3365c9687601
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