An assessment of the ocular tear film in patients with thyroid disorders

Saud A Alanazi,1 Abdullah A Alomran,1 Ali Abusharha,1 Raied Fagehi,1 Naji J Al-Johani,2 Gamal A El-Hiti,1 Ali M Masmali11Cornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia; 2Comprehensive Cancer Center, Department of...

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Autores principales:	Alanazi SA, Alomran AA, Abusharha A, Fagehi R, Al-Johani NJ, El-Hiti GA, Masmali AM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	dry eye thyroid gland disorders phenol red thread test tear break-up time test tear ferning patterns ocular tear film Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/2916acb4281a4b8e84e31c55305f80f9
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spelling	oai:doaj.org-article:2916acb4281a4b8e84e31c55305f80f92021-12-02T09:52:10ZAn assessment of the ocular tear film in patients with thyroid disorders1177-5483https://doaj.org/article/2916acb4281a4b8e84e31c55305f80f92019-06-01T00:00:00Zhttps://www.dovepress.com/an-assessment-of-the-ocular-tear-film-in-patients-with-thyroid-disorde-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Saud A Alanazi,1 Abdullah A Alomran,1 Ali Abusharha,1 Raied Fagehi,1 Naji J Al-Johani,2 Gamal A El-Hiti,1 Ali M Masmali11Cornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia; 2Comprehensive Cancer Center, Department of Endocrinology and Thyroid Oncology, King Fahad Medical City, Riyadh, Saudi ArabiaObjective: To investigate the ocular tear film in patients with thyroid disorders using various tests.Methods: The study involved the assessment of the ocular tear film in 20 patients with thyroid disorders (6 men and 14 women) aged 18–43 years (mean±standard deviation=34.3±3.2 years). An age-matched control group consisting of 20 subjects (8 males and 12 females) ranging in age from 18 to 43 years (31.3±2.9 years) was also examined under similar conditions. All patients completed the Ocular Surface Disease Index questionnaire, followed by the tear ferning test within the right eye. A phenol red thread test was carried out 10 mins later followed by the fluorescein tear break-up test with a 10-min gap between the tests being implemented.Results: The median score for the Ocular Surface Disease Index (P<0.05) showed the condition of mild dry eyes [median (IQR)=15.5 (21.9)] in patients with thyroid disorders compared to the control group [5.6 (3.6)]. The mean score for the phenol red thread test within both the right and left eyes showed acceptable tear volumes of 11.7±8.1 and 10.5±7.4 mm, respectively, but this was much lower (P<0.05) compared to those recorded within the control group (22.2±6.5 and 20.7±5.2 mm, respectively). In addition, the mean for the tear break-up time (P<0.05) scores in both eyes within the patients with thyroid disorders revealed a certain degree of eye dryness (4.9±1.6 and 4.2±1.9 s), while the control group showed normal eye scores (13.2±2.6 and 12.3±2.2 s). The median score for tear ferning grades showed eye dryness [2.0 (2.2)] within the study group and normal eyes [1.2 (0.9)] within the control group.Conclusions: Patients with thyroid disorders have a significant level of eye dryness compared to normal eye subjects.Keywords: dry eye, thyroid gland disorders, phenol red thread test, tear break-up time test, tear ferning patterns, ocular tear filmAlanazi SAAlomran AAAbusharha AFagehi RAl-Johani NJEl-Hiti GAMasmali AMDove Medical Pressarticledry eyethyroid gland disordersphenol red thread testtear break-up time testtear ferning patternsocular tear filmOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1019-1026 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	dry eye thyroid gland disorders phenol red thread test tear break-up time test tear ferning patterns ocular tear film Ophthalmology RE1-994
spellingShingle	dry eye thyroid gland disorders phenol red thread test tear break-up time test tear ferning patterns ocular tear film Ophthalmology RE1-994 Alanazi SA Alomran AA Abusharha A Fagehi R Al-Johani NJ El-Hiti GA Masmali AM An assessment of the ocular tear film in patients with thyroid disorders
description	Saud A Alanazi,1 Abdullah A Alomran,1 Ali Abusharha,1 Raied Fagehi,1 Naji J Al-Johani,2 Gamal A El-Hiti,1 Ali M Masmali11Cornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia; 2Comprehensive Cancer Center, Department of Endocrinology and Thyroid Oncology, King Fahad Medical City, Riyadh, Saudi ArabiaObjective: To investigate the ocular tear film in patients with thyroid disorders using various tests.Methods: The study involved the assessment of the ocular tear film in 20 patients with thyroid disorders (6 men and 14 women) aged 18–43 years (mean±standard deviation=34.3±3.2 years). An age-matched control group consisting of 20 subjects (8 males and 12 females) ranging in age from 18 to 43 years (31.3±2.9 years) was also examined under similar conditions. All patients completed the Ocular Surface Disease Index questionnaire, followed by the tear ferning test within the right eye. A phenol red thread test was carried out 10 mins later followed by the fluorescein tear break-up test with a 10-min gap between the tests being implemented.Results: The median score for the Ocular Surface Disease Index (P<0.05) showed the condition of mild dry eyes [median (IQR)=15.5 (21.9)] in patients with thyroid disorders compared to the control group [5.6 (3.6)]. The mean score for the phenol red thread test within both the right and left eyes showed acceptable tear volumes of 11.7±8.1 and 10.5±7.4 mm, respectively, but this was much lower (P<0.05) compared to those recorded within the control group (22.2±6.5 and 20.7±5.2 mm, respectively). In addition, the mean for the tear break-up time (P<0.05) scores in both eyes within the patients with thyroid disorders revealed a certain degree of eye dryness (4.9±1.6 and 4.2±1.9 s), while the control group showed normal eye scores (13.2±2.6 and 12.3±2.2 s). The median score for tear ferning grades showed eye dryness [2.0 (2.2)] within the study group and normal eyes [1.2 (0.9)] within the control group.Conclusions: Patients with thyroid disorders have a significant level of eye dryness compared to normal eye subjects.Keywords: dry eye, thyroid gland disorders, phenol red thread test, tear break-up time test, tear ferning patterns, ocular tear film
format	article
author	Alanazi SA Alomran AA Abusharha A Fagehi R Al-Johani NJ El-Hiti GA Masmali AM
author_facet	Alanazi SA Alomran AA Abusharha A Fagehi R Al-Johani NJ El-Hiti GA Masmali AM
author_sort	Alanazi SA
title	An assessment of the ocular tear film in patients with thyroid disorders
title_short	An assessment of the ocular tear film in patients with thyroid disorders
title_full	An assessment of the ocular tear film in patients with thyroid disorders
title_fullStr	An assessment of the ocular tear film in patients with thyroid disorders
title_full_unstemmed	An assessment of the ocular tear film in patients with thyroid disorders
title_sort	assessment of the ocular tear film in patients with thyroid disorders
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/2916acb4281a4b8e84e31c55305f80f9
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An assessment of the ocular tear film in patients with thyroid disorders

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