The impact of the 2014 Ebola epidemic on HIV disease burden and outcomes in Liberia West Africa.

<h4>Background</h4>Detailed longitudinal studies of HIV-positive individuals in West Africa are lacking. Here the HIV prevalence, incidence, all-cause mortality, and the proportion of individuals receiving treatment with cART in two cohorts of participants in Ebola-related studies are de...

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Autores principales:	Soka J Moses, Ian Wachekwa, Collin Van Ryn, Greg Grandits, Alice Pau, Moses Badio, Stephen B Kennedy, Michael C Sneller, Elizabeth S Higgs, H Clifford Lane, Mosoka Fallah, Stephen A Migueles, Cavan Reilly
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/291749d6fcbc4e2d8c3d627c95c1f990
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spelling	oai:doaj.org-article:291749d6fcbc4e2d8c3d627c95c1f9902021-12-02T20:08:20ZThe impact of the 2014 Ebola epidemic on HIV disease burden and outcomes in Liberia West Africa.1932-620310.1371/journal.pone.0257049https://doaj.org/article/291749d6fcbc4e2d8c3d627c95c1f9902021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257049https://doaj.org/toc/1932-6203<h4>Background</h4>Detailed longitudinal studies of HIV-positive individuals in West Africa are lacking. Here the HIV prevalence, incidence, all-cause mortality, and the proportion of individuals receiving treatment with cART in two cohorts of participants in Ebola-related studies are described.<h4>Setting</h4>Individuals of all ages were enrolled and followed at four sites in the area of Monrovia, Liberia.<h4>Methods</h4>Two cohorts identified in response to the Ebola epidemic are described to provide insights into the current state of the HIV epidemic. HIV testing was performed at baseline for participants in both cohorts and during follow-up in one cohort.<h4>Results</h4>Prevalence and incidence of HIV (prevalence of 3.1% for women and 1.4% for men and incidence of 3.3 per 1,000) were higher in these cohorts compared to 2018 national estimates (prevalence of 1.3% and incidence of 0.39 per 1,000). Most participants testing positive did not know their status prior to testing. Of those who knew they were HIV positive, 7.9% reported being on antiretroviral treatment. The death rate among those with HIV was 12.3% compared to 1.9% in HIV-negative individuals (adjusted odds ratio of 6.87). While higher levels of d-dimer were associated with increased mortality, this was not specific to those with HIV, however lower hemoglobin levels were associated with increased mortality among those with HIV.<h4>Conclusion</h4>These findings point to a need to perform further research studies aimed at fulfilling these knowledge gaps and address current shortcomings in the provision of care for those living with HIV in Liberia.Soka J MosesIan WachekwaCollin Van RynGreg GranditsAlice PauMoses BadioStephen B KennedyMichael C SnellerElizabeth S HiggsH Clifford LaneMosoka FallahStephen A MiguelesCavan ReillyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257049 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Soka J Moses Ian Wachekwa Collin Van Ryn Greg Grandits Alice Pau Moses Badio Stephen B Kennedy Michael C Sneller Elizabeth S Higgs H Clifford Lane Mosoka Fallah Stephen A Migueles Cavan Reilly The impact of the 2014 Ebola epidemic on HIV disease burden and outcomes in Liberia West Africa.
description	<h4>Background</h4>Detailed longitudinal studies of HIV-positive individuals in West Africa are lacking. Here the HIV prevalence, incidence, all-cause mortality, and the proportion of individuals receiving treatment with cART in two cohorts of participants in Ebola-related studies are described.<h4>Setting</h4>Individuals of all ages were enrolled and followed at four sites in the area of Monrovia, Liberia.<h4>Methods</h4>Two cohorts identified in response to the Ebola epidemic are described to provide insights into the current state of the HIV epidemic. HIV testing was performed at baseline for participants in both cohorts and during follow-up in one cohort.<h4>Results</h4>Prevalence and incidence of HIV (prevalence of 3.1% for women and 1.4% for men and incidence of 3.3 per 1,000) were higher in these cohorts compared to 2018 national estimates (prevalence of 1.3% and incidence of 0.39 per 1,000). Most participants testing positive did not know their status prior to testing. Of those who knew they were HIV positive, 7.9% reported being on antiretroviral treatment. The death rate among those with HIV was 12.3% compared to 1.9% in HIV-negative individuals (adjusted odds ratio of 6.87). While higher levels of d-dimer were associated with increased mortality, this was not specific to those with HIV, however lower hemoglobin levels were associated with increased mortality among those with HIV.<h4>Conclusion</h4>These findings point to a need to perform further research studies aimed at fulfilling these knowledge gaps and address current shortcomings in the provision of care for those living with HIV in Liberia.
format	article
author	Soka J Moses Ian Wachekwa Collin Van Ryn Greg Grandits Alice Pau Moses Badio Stephen B Kennedy Michael C Sneller Elizabeth S Higgs H Clifford Lane Mosoka Fallah Stephen A Migueles Cavan Reilly
author_facet	Soka J Moses Ian Wachekwa Collin Van Ryn Greg Grandits Alice Pau Moses Badio Stephen B Kennedy Michael C Sneller Elizabeth S Higgs H Clifford Lane Mosoka Fallah Stephen A Migueles Cavan Reilly
author_sort	Soka J Moses
title	The impact of the 2014 Ebola epidemic on HIV disease burden and outcomes in Liberia West Africa.
title_short	The impact of the 2014 Ebola epidemic on HIV disease burden and outcomes in Liberia West Africa.
title_full	The impact of the 2014 Ebola epidemic on HIV disease burden and outcomes in Liberia West Africa.
title_fullStr	The impact of the 2014 Ebola epidemic on HIV disease burden and outcomes in Liberia West Africa.
title_full_unstemmed	The impact of the 2014 Ebola epidemic on HIV disease burden and outcomes in Liberia West Africa.
title_sort	impact of the 2014 ebola epidemic on hiv disease burden and outcomes in liberia west africa.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/291749d6fcbc4e2d8c3d627c95c1f990
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The impact of the 2014 Ebola epidemic on HIV disease burden and outcomes in Liberia West Africa.

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