High molecular weight adiponectin levels are inversely associated with adiposity in pediatric brain tumor survivors

Abstract While children with brain tumors are surviving at record rates, survivors are at risk of cardiovascular disease and type 2 diabetes mellitus; these conditions may be driven by excess body fat. Adiponectin in an adipokine that is inversely associated with the fat mass, and has been linked to...

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Autores principales:	Rebecca Ronsley, Shahrad Rod Rassekh, Adam Fleming, Brianna Empringham, William Jennings, Carol Portwine, Sarah Burrow, Shayna Zelcer, Donna L. Johnston, Lehana Thabane, M. Constantine Samaan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/29199f71613041b7a3dd85f406e5a55e
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spelling	oai:doaj.org-article:29199f71613041b7a3dd85f406e5a55e2021-12-02T15:09:48ZHigh molecular weight adiponectin levels are inversely associated with adiposity in pediatric brain tumor survivors10.1038/s41598-020-75638-w2045-2322https://doaj.org/article/29199f71613041b7a3dd85f406e5a55e2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-75638-whttps://doaj.org/toc/2045-2322Abstract While children with brain tumors are surviving at record rates, survivors are at risk of cardiovascular disease and type 2 diabetes mellitus; these conditions may be driven by excess body fat. Adiponectin in an adipokine that is inversely associated with the fat mass, and has been linked to cardiometabolic risk stratification in the general population. However, adiponectin’s profile and determinants in SCBT have not been established. We tested the hypothesis that high molecular weight (HMW) adiponectin levels, the more biologically active form of adiponectin, were associated with adiposity in SCBT similarly to non-cancer controls. Seventy-four SCBT (n = 32 female) and 126 controls (n = 59 female) who were 5–17 years old were included. Partial correlations and multivariable regression analyses assessed the relationship between HMW adiponectin and adiposity. HMW adiponectin was inversely associated with total and central adiposity (FM%: β − 0.21, 95% CI − 0.15, − 0.08; p value < 0.0001; WHR: β − 0.14, 95% CI − 0.02, − 0.01; p value < 0.0001 ;WHtR: β − 0.21, 95% CI − 0.05, − 0.03; p value < 0.0001). In conclusion, HMW adiponectin is inversely correlated with adiposity in SCBT. Adiponectin may serve as a biomarker of cardiometabolic risk and response to interventions to prevent and manage obesity and its comorbidities in SCBT.Rebecca RonsleyShahrad Rod RassekhAdam FlemingBrianna EmpringhamWilliam JenningsCarol PortwineSarah BurrowShayna ZelcerDonna L. JohnstonLehana ThabaneM. Constantine SamaanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rebecca Ronsley Shahrad Rod Rassekh Adam Fleming Brianna Empringham William Jennings Carol Portwine Sarah Burrow Shayna Zelcer Donna L. Johnston Lehana Thabane M. Constantine Samaan High molecular weight adiponectin levels are inversely associated with adiposity in pediatric brain tumor survivors
description	Abstract While children with brain tumors are surviving at record rates, survivors are at risk of cardiovascular disease and type 2 diabetes mellitus; these conditions may be driven by excess body fat. Adiponectin in an adipokine that is inversely associated with the fat mass, and has been linked to cardiometabolic risk stratification in the general population. However, adiponectin’s profile and determinants in SCBT have not been established. We tested the hypothesis that high molecular weight (HMW) adiponectin levels, the more biologically active form of adiponectin, were associated with adiposity in SCBT similarly to non-cancer controls. Seventy-four SCBT (n = 32 female) and 126 controls (n = 59 female) who were 5–17 years old were included. Partial correlations and multivariable regression analyses assessed the relationship between HMW adiponectin and adiposity. HMW adiponectin was inversely associated with total and central adiposity (FM%: β − 0.21, 95% CI − 0.15, − 0.08; p value < 0.0001; WHR: β − 0.14, 95% CI − 0.02, − 0.01; p value < 0.0001 ;WHtR: β − 0.21, 95% CI − 0.05, − 0.03; p value < 0.0001). In conclusion, HMW adiponectin is inversely correlated with adiposity in SCBT. Adiponectin may serve as a biomarker of cardiometabolic risk and response to interventions to prevent and manage obesity and its comorbidities in SCBT.
format	article
author	Rebecca Ronsley Shahrad Rod Rassekh Adam Fleming Brianna Empringham William Jennings Carol Portwine Sarah Burrow Shayna Zelcer Donna L. Johnston Lehana Thabane M. Constantine Samaan
author_facet	Rebecca Ronsley Shahrad Rod Rassekh Adam Fleming Brianna Empringham William Jennings Carol Portwine Sarah Burrow Shayna Zelcer Donna L. Johnston Lehana Thabane M. Constantine Samaan
author_sort	Rebecca Ronsley
title	High molecular weight adiponectin levels are inversely associated with adiposity in pediatric brain tumor survivors
title_short	High molecular weight adiponectin levels are inversely associated with adiposity in pediatric brain tumor survivors
title_full	High molecular weight adiponectin levels are inversely associated with adiposity in pediatric brain tumor survivors
title_fullStr	High molecular weight adiponectin levels are inversely associated with adiposity in pediatric brain tumor survivors
title_full_unstemmed	High molecular weight adiponectin levels are inversely associated with adiposity in pediatric brain tumor survivors
title_sort	high molecular weight adiponectin levels are inversely associated with adiposity in pediatric brain tumor survivors
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/29199f71613041b7a3dd85f406e5a55e
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High molecular weight adiponectin levels are inversely associated with adiposity in pediatric brain tumor survivors

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