Status of metals in serum and urine samples of chronic kidney disease patients in a rural area of Bangladesh: An observational study

The traditional causes of Chronic Kidney Damage (CKD) are Diabetes and Hypertension. However, recent studies reported the possible relations between metal exposure and CKD. This study aims to explore the status of metals in CKD patients compared to their healthy counterparts at Narayanganj, Banglade...

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Autores principales:	Tasrina Rabia Choudhury, Sk. Zubaer Zaman, Tanzina Iveen Chowdhury, Bilkis Ara Begum, Md. Anwarul Islam, Md. Mostafizur Rahman
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	CKD Copper Zinc Urine Cadmium Chromium Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/291a2c8f10fe44bca4a0e80d30c1e520
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spelling	oai:doaj.org-article:291a2c8f10fe44bca4a0e80d30c1e5202021-12-02T05:02:57ZStatus of metals in serum and urine samples of chronic kidney disease patients in a rural area of Bangladesh: An observational study2405-844010.1016/j.heliyon.2021.e08382https://doaj.org/article/291a2c8f10fe44bca4a0e80d30c1e5202021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021024853https://doaj.org/toc/2405-8440The traditional causes of Chronic Kidney Damage (CKD) are Diabetes and Hypertension. However, recent studies reported the possible relations between metal exposure and CKD. This study aims to explore the status of metals in CKD patients compared to their healthy counterparts at Narayanganj, Bangladesh, through a cross-sectional study. In this study, 50 volunteers were involved; 30 CKD patients and 20 healthy controls. Five metals were measured from serum [Copper (Cu) and Zinc (Zn)] and urine [Lead (Pb), Cadmium (Cd), and Chromium (Cr)] using Atomic Absorption Spectrometry. Compared to the controls the CKD patients exhibited significantly higher levels of Pb, Cd and Cr levels in their urine samples. This signifies a potential association between heavy metal exposure and CKD. The serum levels of Cu were much higher than expected for CKD patients than controls, and the Zn values were in accordance with established literature. However, the level of Zn in blood was significantly lower in the CKD group compared to the control. This data suggests that the Cu imbalance in the serum of the CKD subjects might have been related to a myriad of reasons, the most plausible of which being exposed to large concentrations of the nephrotoxic metals such as Pb, Cd and Cr in this study. Our study has shed a much needed light on the correlation between CKD and exposure to heavy metals and imbalance of essential metals in blood serum, in a rural locality of Bangladesh.Tasrina Rabia ChoudhurySk. Zubaer ZamanTanzina Iveen ChowdhuryBilkis Ara BegumMd. Anwarul IslamMd. Mostafizur RahmanElsevierarticleCKDCopperZincUrineCadmiumChromiumScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08382- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CKD Copper Zinc Urine Cadmium Chromium Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	CKD Copper Zinc Urine Cadmium Chromium Science (General) Q1-390 Social sciences (General) H1-99 Tasrina Rabia Choudhury Sk. Zubaer Zaman Tanzina Iveen Chowdhury Bilkis Ara Begum Md. Anwarul Islam Md. Mostafizur Rahman Status of metals in serum and urine samples of chronic kidney disease patients in a rural area of Bangladesh: An observational study
description	The traditional causes of Chronic Kidney Damage (CKD) are Diabetes and Hypertension. However, recent studies reported the possible relations between metal exposure and CKD. This study aims to explore the status of metals in CKD patients compared to their healthy counterparts at Narayanganj, Bangladesh, through a cross-sectional study. In this study, 50 volunteers were involved; 30 CKD patients and 20 healthy controls. Five metals were measured from serum [Copper (Cu) and Zinc (Zn)] and urine [Lead (Pb), Cadmium (Cd), and Chromium (Cr)] using Atomic Absorption Spectrometry. Compared to the controls the CKD patients exhibited significantly higher levels of Pb, Cd and Cr levels in their urine samples. This signifies a potential association between heavy metal exposure and CKD. The serum levels of Cu were much higher than expected for CKD patients than controls, and the Zn values were in accordance with established literature. However, the level of Zn in blood was significantly lower in the CKD group compared to the control. This data suggests that the Cu imbalance in the serum of the CKD subjects might have been related to a myriad of reasons, the most plausible of which being exposed to large concentrations of the nephrotoxic metals such as Pb, Cd and Cr in this study. Our study has shed a much needed light on the correlation between CKD and exposure to heavy metals and imbalance of essential metals in blood serum, in a rural locality of Bangladesh.
format	article
author	Tasrina Rabia Choudhury Sk. Zubaer Zaman Tanzina Iveen Chowdhury Bilkis Ara Begum Md. Anwarul Islam Md. Mostafizur Rahman
author_facet	Tasrina Rabia Choudhury Sk. Zubaer Zaman Tanzina Iveen Chowdhury Bilkis Ara Begum Md. Anwarul Islam Md. Mostafizur Rahman
author_sort	Tasrina Rabia Choudhury
title	Status of metals in serum and urine samples of chronic kidney disease patients in a rural area of Bangladesh: An observational study
title_short	Status of metals in serum and urine samples of chronic kidney disease patients in a rural area of Bangladesh: An observational study
title_full	Status of metals in serum and urine samples of chronic kidney disease patients in a rural area of Bangladesh: An observational study
title_fullStr	Status of metals in serum and urine samples of chronic kidney disease patients in a rural area of Bangladesh: An observational study
title_full_unstemmed	Status of metals in serum and urine samples of chronic kidney disease patients in a rural area of Bangladesh: An observational study
title_sort	status of metals in serum and urine samples of chronic kidney disease patients in a rural area of bangladesh: an observational study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/291a2c8f10fe44bca4a0e80d30c1e520
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Status of metals in serum and urine samples of chronic kidney disease patients in a rural area of Bangladesh: An observational study

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