Quantitative Assessment of Three-Dimensional Choroidal Vascularity and Choriocapillaris Flow Signal Voids in Myopic Patients Using SS-OCTA

Purpose: To compare the choroidal vascularity of large- and middle-sized choroidal vessels and choriocapillaris (CC) perfusion in patients with different degrees of myopia using swept-source optical coherence tomography angiography (SS-OCTA). Methods: One hundred and thirteen people with myopia were...

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Autores principales:	Amin Xu, Gongpeng Sun, Chaoye Duan, Zhen Chen, Changzheng Chen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	myopia three-dimensional choroidal vascularity index choriocapillaris flow signal voids swept-source optical coherence tomography angiography Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/291d82ddf5b34e13a16e127a6dfd2cd6
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spelling	oai:doaj.org-article:291d82ddf5b34e13a16e127a6dfd2cd62021-11-25T17:20:10ZQuantitative Assessment of Three-Dimensional Choroidal Vascularity and Choriocapillaris Flow Signal Voids in Myopic Patients Using SS-OCTA10.3390/diagnostics111119482075-4418https://doaj.org/article/291d82ddf5b34e13a16e127a6dfd2cd62021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/1948https://doaj.org/toc/2075-4418Purpose: To compare the choroidal vascularity of large- and middle-sized choroidal vessels and choriocapillaris (CC) perfusion in patients with different degrees of myopia using swept-source optical coherence tomography angiography (SS-OCTA). Methods: One hundred and thirteen people with myopia were enrolled. SS-OCTA was performed to analyze the choroidal vascularity and CC perfusion. Three-dimensional (3D) choroidal vascularity index (CVI) and choroidal luminal volumes (LV) were obtained by artificial intelligence segmentation of the choroidal lumen in Volume OCT images. CC perfusion was assessed by flow signal voids (FSVs). Results: In the macular, multiple linear regression model showed that choroidal thickness (CT), total choroidal volume, LV, and choroidal stromal volume were negatively correlated with axis length (AL), respectively (all <i>p</i> < 0.001). Three dimensional CVI was negatively associated with AL (<i>p</i> < 0.05). FSV% was positively correlated with age only (<i>p</i> < 0.001). Additionally, after adjustment for age and AL, FSV% had a significant negative correlation with CT (<i>p</i> < 0.05). Conclusion: Choroidal vascularity decreases gradually with increasing severity of myopia. The decrease of CC blood perfusion was related to a higher severity of myopia and the thinning of choroid.Amin XuGongpeng SunChaoye DuanZhen ChenChangzheng ChenMDPI AGarticlemyopiathree-dimensional choroidal vascularity indexchoriocapillarisflow signal voidsswept-source optical coherence tomography angiographyMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 1948, p 1948 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	myopia three-dimensional choroidal vascularity index choriocapillaris flow signal voids swept-source optical coherence tomography angiography Medicine (General) R5-920
spellingShingle	myopia three-dimensional choroidal vascularity index choriocapillaris flow signal voids swept-source optical coherence tomography angiography Medicine (General) R5-920 Amin Xu Gongpeng Sun Chaoye Duan Zhen Chen Changzheng Chen Quantitative Assessment of Three-Dimensional Choroidal Vascularity and Choriocapillaris Flow Signal Voids in Myopic Patients Using SS-OCTA
description	Purpose: To compare the choroidal vascularity of large- and middle-sized choroidal vessels and choriocapillaris (CC) perfusion in patients with different degrees of myopia using swept-source optical coherence tomography angiography (SS-OCTA). Methods: One hundred and thirteen people with myopia were enrolled. SS-OCTA was performed to analyze the choroidal vascularity and CC perfusion. Three-dimensional (3D) choroidal vascularity index (CVI) and choroidal luminal volumes (LV) were obtained by artificial intelligence segmentation of the choroidal lumen in Volume OCT images. CC perfusion was assessed by flow signal voids (FSVs). Results: In the macular, multiple linear regression model showed that choroidal thickness (CT), total choroidal volume, LV, and choroidal stromal volume were negatively correlated with axis length (AL), respectively (all <i>p</i> < 0.001). Three dimensional CVI was negatively associated with AL (<i>p</i> < 0.05). FSV% was positively correlated with age only (<i>p</i> < 0.001). Additionally, after adjustment for age and AL, FSV% had a significant negative correlation with CT (<i>p</i> < 0.05). Conclusion: Choroidal vascularity decreases gradually with increasing severity of myopia. The decrease of CC blood perfusion was related to a higher severity of myopia and the thinning of choroid.
format	article
author	Amin Xu Gongpeng Sun Chaoye Duan Zhen Chen Changzheng Chen
author_facet	Amin Xu Gongpeng Sun Chaoye Duan Zhen Chen Changzheng Chen
author_sort	Amin Xu
title	Quantitative Assessment of Three-Dimensional Choroidal Vascularity and Choriocapillaris Flow Signal Voids in Myopic Patients Using SS-OCTA
title_short	Quantitative Assessment of Three-Dimensional Choroidal Vascularity and Choriocapillaris Flow Signal Voids in Myopic Patients Using SS-OCTA
title_full	Quantitative Assessment of Three-Dimensional Choroidal Vascularity and Choriocapillaris Flow Signal Voids in Myopic Patients Using SS-OCTA
title_fullStr	Quantitative Assessment of Three-Dimensional Choroidal Vascularity and Choriocapillaris Flow Signal Voids in Myopic Patients Using SS-OCTA
title_full_unstemmed	Quantitative Assessment of Three-Dimensional Choroidal Vascularity and Choriocapillaris Flow Signal Voids in Myopic Patients Using SS-OCTA
title_sort	quantitative assessment of three-dimensional choroidal vascularity and choriocapillaris flow signal voids in myopic patients using ss-octa
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/291d82ddf5b34e13a16e127a6dfd2cd6
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Quantitative Assessment of Three-Dimensional Choroidal Vascularity and Choriocapillaris Flow Signal Voids in Myopic Patients Using SS-OCTA

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