A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy

The neural circuits through which the substantia nigra pars reticulata (SNr) exerts its role in epilepsy control are not known. Here the authors reveal that a long-range SNr-parafascicular nucleus disinhibitory circuit participates in regulating seizures in temporal lobe epilepsy and inhibition of t...

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Autores principales:	Bin Chen, Cenglin Xu, Yi Wang, Wenkai Lin, Ying Wang, Liying Chen, Heming Cheng, Lingyu Xu, Tingting Hu, Junli Zhao, Ping Dong, Yi Guo, Shihong Zhang, Shuang Wang, Yudong Zhou, Weiwei Hu, Shuming Duan, Zhong Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/29241ff20df247bfae9f0ed1d9d0bb7a
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spelling	oai:doaj.org-article:29241ff20df247bfae9f0ed1d9d0bb7a2021-12-02T16:56:33ZA disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy10.1038/s41467-020-14648-82041-1723https://doaj.org/article/29241ff20df247bfae9f0ed1d9d0bb7a2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14648-8https://doaj.org/toc/2041-1723The neural circuits through which the substantia nigra pars reticulata (SNr) exerts its role in epilepsy control are not known. Here the authors reveal that a long-range SNr-parafascicular nucleus disinhibitory circuit participates in regulating seizures in temporal lobe epilepsy and inhibition of this circuit can alleviate severity of epileptic seizures.Bin ChenCenglin XuYi WangWenkai LinYing WangLiying ChenHeming ChengLingyu XuTingting HuJunli ZhaoPing DongYi GuoShihong ZhangShuang WangYudong ZhouWeiwei HuShuming DuanZhong ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bin Chen Cenglin Xu Yi Wang Wenkai Lin Ying Wang Liying Chen Heming Cheng Lingyu Xu Tingting Hu Junli Zhao Ping Dong Yi Guo Shihong Zhang Shuang Wang Yudong Zhou Weiwei Hu Shuming Duan Zhong Chen A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy
description	The neural circuits through which the substantia nigra pars reticulata (SNr) exerts its role in epilepsy control are not known. Here the authors reveal that a long-range SNr-parafascicular nucleus disinhibitory circuit participates in regulating seizures in temporal lobe epilepsy and inhibition of this circuit can alleviate severity of epileptic seizures.
format	article
author	Bin Chen Cenglin Xu Yi Wang Wenkai Lin Ying Wang Liying Chen Heming Cheng Lingyu Xu Tingting Hu Junli Zhao Ping Dong Yi Guo Shihong Zhang Shuang Wang Yudong Zhou Weiwei Hu Shuming Duan Zhong Chen
author_facet	Bin Chen Cenglin Xu Yi Wang Wenkai Lin Ying Wang Liying Chen Heming Cheng Lingyu Xu Tingting Hu Junli Zhao Ping Dong Yi Guo Shihong Zhang Shuang Wang Yudong Zhou Weiwei Hu Shuming Duan Zhong Chen
author_sort	Bin Chen
title	A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy
title_short	A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy
title_full	A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy
title_fullStr	A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy
title_full_unstemmed	A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy
title_sort	disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/29241ff20df247bfae9f0ed1d9d0bb7a
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A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy

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