CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

CDK4/6-Cyclin D pathway is often deregulated in cancer; therefore specific inhibitors have been developed. Here the authors show that treatment with CDK4/6 inhibitors activate autophagy in breast cancer cells; thus, combination of such inhibitors with autophagy inhibitors results in a synergistic ef...

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Autores principales:	Smruthi Vijayaraghavan, Cansu Karakas, Iman Doostan, Xian Chen, Tuyen Bui, Min Yi, Akshara S. Raghavendra, Yang Zhao, Sami I. Bashour, Nuhad K. Ibrahim, Meghan Karuturi, Jing Wang, Jeffrey D. Winkler, Ravi K. Amaravadi, Kelly K. Hunt, Debu Tripathy, Khandan Keyomarsi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/29244e97db3b4325b02bb495622f99c7
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spelling	oai:doaj.org-article:29244e97db3b4325b02bb495622f99c72021-12-02T14:40:21ZCDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers10.1038/ncomms159162041-1723https://doaj.org/article/29244e97db3b4325b02bb495622f99c72017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15916https://doaj.org/toc/2041-1723CDK4/6-Cyclin D pathway is often deregulated in cancer; therefore specific inhibitors have been developed. Here the authors show that treatment with CDK4/6 inhibitors activate autophagy in breast cancer cells; thus, combination of such inhibitors with autophagy inhibitors results in a synergistic effect on tumour growth.Smruthi VijayaraghavanCansu KarakasIman DoostanXian ChenTuyen BuiMin YiAkshara S. RaghavendraYang ZhaoSami I. BashourNuhad K. IbrahimMeghan KaruturiJing WangJeffrey D. WinklerRavi K. AmaravadiKelly K. HuntDebu TripathyKhandan KeyomarsiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Smruthi Vijayaraghavan Cansu Karakas Iman Doostan Xian Chen Tuyen Bui Min Yi Akshara S. Raghavendra Yang Zhao Sami I. Bashour Nuhad K. Ibrahim Meghan Karuturi Jing Wang Jeffrey D. Winkler Ravi K. Amaravadi Kelly K. Hunt Debu Tripathy Khandan Keyomarsi CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers
description	CDK4/6-Cyclin D pathway is often deregulated in cancer; therefore specific inhibitors have been developed. Here the authors show that treatment with CDK4/6 inhibitors activate autophagy in breast cancer cells; thus, combination of such inhibitors with autophagy inhibitors results in a synergistic effect on tumour growth.
format	article
author	Smruthi Vijayaraghavan Cansu Karakas Iman Doostan Xian Chen Tuyen Bui Min Yi Akshara S. Raghavendra Yang Zhao Sami I. Bashour Nuhad K. Ibrahim Meghan Karuturi Jing Wang Jeffrey D. Winkler Ravi K. Amaravadi Kelly K. Hunt Debu Tripathy Khandan Keyomarsi
author_facet	Smruthi Vijayaraghavan Cansu Karakas Iman Doostan Xian Chen Tuyen Bui Min Yi Akshara S. Raghavendra Yang Zhao Sami I. Bashour Nuhad K. Ibrahim Meghan Karuturi Jing Wang Jeffrey D. Winkler Ravi K. Amaravadi Kelly K. Hunt Debu Tripathy Khandan Keyomarsi
author_sort	Smruthi Vijayaraghavan
title	CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers
title_short	CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers
title_full	CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers
title_fullStr	CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers
title_full_unstemmed	CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers
title_sort	cdk4/6 and autophagy inhibitors synergistically induce senescence in rb positive cytoplasmic cyclin e negative cancers
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/29244e97db3b4325b02bb495622f99c7
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CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

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