Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes

Understanding patient-specific pathobiological pathways is a critical step for advancing precision medicine. Here the authors show that individualized protein-protein interaction networks provide key insight on patient-level pathobiology and clinically relevant pathophenotypic characteristics in a c...

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Autores principales:	Bradley A. Maron, Rui-Sheng Wang, Sergei Shevtsov, Stavros G. Drakos, Elena Arons, Omar Wever-Pinzon, Gordon S. Huggins, Andriy O. Samokhin, William M. Oldham, Yasmine Aguib, Magdi H. Yacoub, Ethan J. Rowin, Barry J. Maron, Martin S. Maron, Joseph Loscalzo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2926174a581e4c769ceef9c3aba4d547
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spelling	oai:doaj.org-article:2926174a581e4c769ceef9c3aba4d5472021-12-02T14:10:56ZIndividualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes10.1038/s41467-021-21146-y2041-1723https://doaj.org/article/2926174a581e4c769ceef9c3aba4d5472021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21146-yhttps://doaj.org/toc/2041-1723Understanding patient-specific pathobiological pathways is a critical step for advancing precision medicine. Here the authors show that individualized protein-protein interaction networks provide key insight on patient-level pathobiology and clinically relevant pathophenotypic characteristics in a complex disease.Bradley A. MaronRui-Sheng WangSergei ShevtsovStavros G. DrakosElena AronsOmar Wever-PinzonGordon S. HugginsAndriy O. SamokhinWilliam M. OldhamYasmine AguibMagdi H. YacoubEthan J. RowinBarry J. MaronMartin S. MaronJoseph LoscalzoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bradley A. Maron Rui-Sheng Wang Sergei Shevtsov Stavros G. Drakos Elena Arons Omar Wever-Pinzon Gordon S. Huggins Andriy O. Samokhin William M. Oldham Yasmine Aguib Magdi H. Yacoub Ethan J. Rowin Barry J. Maron Martin S. Maron Joseph Loscalzo Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes
description	Understanding patient-specific pathobiological pathways is a critical step for advancing precision medicine. Here the authors show that individualized protein-protein interaction networks provide key insight on patient-level pathobiology and clinically relevant pathophenotypic characteristics in a complex disease.
format	article
author	Bradley A. Maron Rui-Sheng Wang Sergei Shevtsov Stavros G. Drakos Elena Arons Omar Wever-Pinzon Gordon S. Huggins Andriy O. Samokhin William M. Oldham Yasmine Aguib Magdi H. Yacoub Ethan J. Rowin Barry J. Maron Martin S. Maron Joseph Loscalzo
author_facet	Bradley A. Maron Rui-Sheng Wang Sergei Shevtsov Stavros G. Drakos Elena Arons Omar Wever-Pinzon Gordon S. Huggins Andriy O. Samokhin William M. Oldham Yasmine Aguib Magdi H. Yacoub Ethan J. Rowin Barry J. Maron Martin S. Maron Joseph Loscalzo
author_sort	Bradley A. Maron
title	Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes
title_short	Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes
title_full	Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes
title_fullStr	Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes
title_full_unstemmed	Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes
title_sort	individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2926174a581e4c769ceef9c3aba4d547
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Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes

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