Localized Amyloidosis of the Nasal Mucosa: A Case Report and Review of the Literature
Amyloidosis is a disorder of protein folding in which various proteins automatically aggregate into a highly abnormal fibrillar conformation. Amyloidosis is classified into systemic and localized forms depending on whether the abnormal proteins deposited in several different organs or only a single...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:29278b5420ce4639b5a1ec0a750ba4dd2021-11-05T06:26:42ZLocalized Amyloidosis of the Nasal Mucosa: A Case Report and Review of the Literature2296-875X10.3389/fsurg.2021.774469https://doaj.org/article/29278b5420ce4639b5a1ec0a750ba4dd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fsurg.2021.774469/fullhttps://doaj.org/toc/2296-875XAmyloidosis is a disorder of protein folding in which various proteins automatically aggregate into a highly abnormal fibrillar conformation. Amyloidosis is classified into systemic and localized forms depending on whether the abnormal proteins deposited in several different organs or only a single organ. In localized amyloidosis of the head and neck regions, laryngeal amyloidosis is common; however, localized amyloidosis of the nose is extremely rare. We herein report a case of localized amyloidosis of the nose and review the relevant literature on localized sinonasal amyloidosis. A 41-year-old man presented with a history of severe nasal obstruction, which had persisted for two decades. Nasal endoscopy and imaging studies showed extensive thickening of the bilateral nasal mucosa and diffuse submucosal deposition of calcification. After histopathological and systemic examinations, he was diagnosed with localized amyloidosis of the nasal mucosa. Septoplasty and bilateral inferior turbinoplasty, which consisted of mucosal resection using an ultrasonic bone curette, was performed and his symptoms markedly improved. Localized sinonasal amyloidosis has a good prognosis and surgical resection should be selected as a first-line treatment; however, clinicians should recognize the high probability of recurrence.Hiromasa TakakuraHirohiko TachinoKouji TakiiJohji ImuraHideo ShojakuFrontiers Media S.A.articlelocalized sinonasal amyloidosiscalcificationultrasonic bone curetteclinical featuresdebulking surgerySurgeryRD1-811ENFrontiers in Surgery, Vol 8 (2021) |
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localized sinonasal amyloidosis calcification ultrasonic bone curette clinical features debulking surgery Surgery RD1-811 |
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localized sinonasal amyloidosis calcification ultrasonic bone curette clinical features debulking surgery Surgery RD1-811 Hiromasa Takakura Hirohiko Tachino Kouji Takii Johji Imura Hideo Shojaku Localized Amyloidosis of the Nasal Mucosa: A Case Report and Review of the Literature |
| description |
Amyloidosis is a disorder of protein folding in which various proteins automatically aggregate into a highly abnormal fibrillar conformation. Amyloidosis is classified into systemic and localized forms depending on whether the abnormal proteins deposited in several different organs or only a single organ. In localized amyloidosis of the head and neck regions, laryngeal amyloidosis is common; however, localized amyloidosis of the nose is extremely rare. We herein report a case of localized amyloidosis of the nose and review the relevant literature on localized sinonasal amyloidosis. A 41-year-old man presented with a history of severe nasal obstruction, which had persisted for two decades. Nasal endoscopy and imaging studies showed extensive thickening of the bilateral nasal mucosa and diffuse submucosal deposition of calcification. After histopathological and systemic examinations, he was diagnosed with localized amyloidosis of the nasal mucosa. Septoplasty and bilateral inferior turbinoplasty, which consisted of mucosal resection using an ultrasonic bone curette, was performed and his symptoms markedly improved. Localized sinonasal amyloidosis has a good prognosis and surgical resection should be selected as a first-line treatment; however, clinicians should recognize the high probability of recurrence. |
| format |
article |
| author |
Hiromasa Takakura Hirohiko Tachino Kouji Takii Johji Imura Hideo Shojaku |
| author_facet |
Hiromasa Takakura Hirohiko Tachino Kouji Takii Johji Imura Hideo Shojaku |
| author_sort |
Hiromasa Takakura |
| title |
Localized Amyloidosis of the Nasal Mucosa: A Case Report and Review of the Literature |
| title_short |
Localized Amyloidosis of the Nasal Mucosa: A Case Report and Review of the Literature |
| title_full |
Localized Amyloidosis of the Nasal Mucosa: A Case Report and Review of the Literature |
| title_fullStr |
Localized Amyloidosis of the Nasal Mucosa: A Case Report and Review of the Literature |
| title_full_unstemmed |
Localized Amyloidosis of the Nasal Mucosa: A Case Report and Review of the Literature |
| title_sort |
localized amyloidosis of the nasal mucosa: a case report and review of the literature |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/29278b5420ce4639b5a1ec0a750ba4dd |
| work_keys_str_mv |
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