Association between previously identified loci affecting telomere length and coronary heart disease (CHD) in Han Chinese population

Hui Ding,1 Fen Yan,1 Lin-Lin Zhou,2 Xiu-Hai Ji,3 Xin-Nan Gu,1 Zhi-Wei Tang,1 Ru-Hua Chen11Department of Pulmonary Medicine, The Affiliated Yixing People's Hospital, Jiangsu University, Zhenjiang, Jiangsu Province, 2Department of Cardiology, Affiliated Cixi Hospital, Wenzhou Medical Universit...

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Autores principales:	Ding H, Yan F, Zhou LL, Ji XH, Gu XN, Tang ZW, Chen RH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	coronary heart disease gene leucocyte telomere length Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/29283e5f7f0b486984e1240f3f62b693
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spelling	oai:doaj.org-article:29283e5f7f0b486984e1240f3f62b6932021-12-02T06:35:39ZAssociation between previously identified loci affecting telomere length and coronary heart disease (CHD) in Han Chinese population1178-1998https://doaj.org/article/29283e5f7f0b486984e1240f3f62b6932014-05-01T00:00:00Zhttps://www.dovepress.com/association-between-previously-identified-loci-affecting-telomere-leng-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Hui Ding,1 Fen Yan,1 Lin-Lin Zhou,2 Xiu-Hai Ji,3 Xin-Nan Gu,1 Zhi-Wei Tang,1 Ru-Hua Chen11Department of Pulmonary Medicine, The Affiliated Yixing People's Hospital, Jiangsu University, Zhenjiang, Jiangsu Province, 2Department of Cardiology, Affiliated Cixi Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, 3Department of Oncology, Affiliated Taicang Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu Province, People's Republic of ChinaPurpose: To replicate previously confirmed telomere-length loci in a Chinese Han population with coronary heart disease (CHD), and investigate these loci and the possibility of and age at onset of CHD.Patients and methods: 1514 CHD patients and 2470 normal controls were recruited. Medical data including age, sex, body mass index, lipid profiles, history of hypertension, type 2 diabetes mellitus, and dyslipidemia were collected from all the participants. Seven previously identified single-nucleotide polymorphisms (SNPs) related to leucocyte telomere length were genotyped, including rs10936599 in TERC, rs2736100 in TERT, rs7675998 in NAF1, rs9420907 in OBFC1, rs8105767 in ZNF208, rs755017 in RTEL1, and rs11125529 in ACYP2.Results: No significant difference in genotype frequencies from the Hardy–Weinberg equilibrium test was noted for all tested SNPs both in the CHD patients and the normal controls. No polymorphism was observed for rs9420907, and AA genotype was noted in both the CHD patients and the controls. Neither the genotype nor the allele frequencies of rs2736100, rs8105767, rs11125529, and rs2967374 were significantly different between the CHD patients and the normal controls. For rs10936599 and rs755017, statistical difference was found for the allele frequency but not genotype. Distributions of genotype and allele were significantly different between the two groups for rs7675998. The odds ratio for carriers of CHD was 2.127 (95% confidence interval: 1.909–2.370) for the A allele of rs7675998. By one-way analysis of variance test, rs7675998 was associated with the onset age of CHD. CHD patients with the AA genotype of rs7675998 had significantly lower onset age (P<0.05).Conclusion: In a Chinese Han population, NAF1 gene encoding proteins with known function in telomere biology may influence both the possibility of and the age at onset of CHD, as previously reported in European studies.Keywords: coronary heart disease, gene, leucocyte telomere lengthDing HYan FZhou LLJi XHGu XNTang ZWChen RHDove Medical Pressarticlecoronary heart diseasegeneleucocyte telomere lengthGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 857-861 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	coronary heart disease gene leucocyte telomere length Geriatrics RC952-954.6
spellingShingle	coronary heart disease gene leucocyte telomere length Geriatrics RC952-954.6 Ding H Yan F Zhou LL Ji XH Gu XN Tang ZW Chen RH Association between previously identified loci affecting telomere length and coronary heart disease (CHD) in Han Chinese population
description	Hui Ding,1 Fen Yan,1 Lin-Lin Zhou,2 Xiu-Hai Ji,3 Xin-Nan Gu,1 Zhi-Wei Tang,1 Ru-Hua Chen11Department of Pulmonary Medicine, The Affiliated Yixing People's Hospital, Jiangsu University, Zhenjiang, Jiangsu Province, 2Department of Cardiology, Affiliated Cixi Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, 3Department of Oncology, Affiliated Taicang Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu Province, People's Republic of ChinaPurpose: To replicate previously confirmed telomere-length loci in a Chinese Han population with coronary heart disease (CHD), and investigate these loci and the possibility of and age at onset of CHD.Patients and methods: 1514 CHD patients and 2470 normal controls were recruited. Medical data including age, sex, body mass index, lipid profiles, history of hypertension, type 2 diabetes mellitus, and dyslipidemia were collected from all the participants. Seven previously identified single-nucleotide polymorphisms (SNPs) related to leucocyte telomere length were genotyped, including rs10936599 in TERC, rs2736100 in TERT, rs7675998 in NAF1, rs9420907 in OBFC1, rs8105767 in ZNF208, rs755017 in RTEL1, and rs11125529 in ACYP2.Results: No significant difference in genotype frequencies from the Hardy–Weinberg equilibrium test was noted for all tested SNPs both in the CHD patients and the normal controls. No polymorphism was observed for rs9420907, and AA genotype was noted in both the CHD patients and the controls. Neither the genotype nor the allele frequencies of rs2736100, rs8105767, rs11125529, and rs2967374 were significantly different between the CHD patients and the normal controls. For rs10936599 and rs755017, statistical difference was found for the allele frequency but not genotype. Distributions of genotype and allele were significantly different between the two groups for rs7675998. The odds ratio for carriers of CHD was 2.127 (95% confidence interval: 1.909–2.370) for the A allele of rs7675998. By one-way analysis of variance test, rs7675998 was associated with the onset age of CHD. CHD patients with the AA genotype of rs7675998 had significantly lower onset age (P<0.05).Conclusion: In a Chinese Han population, NAF1 gene encoding proteins with known function in telomere biology may influence both the possibility of and the age at onset of CHD, as previously reported in European studies.Keywords: coronary heart disease, gene, leucocyte telomere length
format	article
author	Ding H Yan F Zhou LL Ji XH Gu XN Tang ZW Chen RH
author_facet	Ding H Yan F Zhou LL Ji XH Gu XN Tang ZW Chen RH
author_sort	Ding H
title	Association between previously identified loci affecting telomere length and coronary heart disease (CHD) in Han Chinese population
title_short	Association between previously identified loci affecting telomere length and coronary heart disease (CHD) in Han Chinese population
title_full	Association between previously identified loci affecting telomere length and coronary heart disease (CHD) in Han Chinese population
title_fullStr	Association between previously identified loci affecting telomere length and coronary heart disease (CHD) in Han Chinese population
title_full_unstemmed	Association between previously identified loci affecting telomere length and coronary heart disease (CHD) in Han Chinese population
title_sort	association between previously identified loci affecting telomere length and coronary heart disease (chd) in han chinese population
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/29283e5f7f0b486984e1240f3f62b693
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Association between previously identified loci affecting telomere length and coronary heart disease (CHD) in Han Chinese population

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