Sex differences in the prognosis of patients with hypertrophic cardiomyopathy

Abstract We investigated sex-related differences in the prognosis of patients with hypertrophic cardiomyopathy (HCM) using the Korea National Health Insurance Service database. From 2010 to 2016, 9524 patients diagnosed with HCM and had more than 1-year follow-up period were analyzed. The primary en...

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Autores principales:	Minkwan Kim, Bongsung Kim, You-Jung Choi, Hyun-Jung Lee, Heesun Lee, Jun-Bean Park, Seung-Pyo Lee, Kyung-Do Han, Yong-Jin Kim, Hyung-Kwan Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/29293cd5ea3c4f78a2b00543e8be01ed
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spelling	oai:doaj.org-article:29293cd5ea3c4f78a2b00543e8be01ed2021-12-02T13:20:20ZSex differences in the prognosis of patients with hypertrophic cardiomyopathy10.1038/s41598-021-84335-12045-2322https://doaj.org/article/29293cd5ea3c4f78a2b00543e8be01ed2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84335-1https://doaj.org/toc/2045-2322Abstract We investigated sex-related differences in the prognosis of patients with hypertrophic cardiomyopathy (HCM) using the Korea National Health Insurance Service database. From 2010 to 2016, 9524 patients diagnosed with HCM and had more than 1-year follow-up period were analyzed. The primary endpoint was the composite of cardiovascular death or new-onset heart failure (HF) admission. Propensity score-matching analysis was performed to adjust for different baseline characteristics. With a 4.4-years’ median follow-up interval (range 2.0–6.6 years) and male predominance (77.6%), women with HCM were older (52.6 ± 9.7 vs. 51.4 ± 9.1, p < 0.001), had lower incomes, more comorbidities based on Charlson comorbidity index. Women with HCM had a higher incidence of the primary endpoint than men (incidence rate: 34.15 vs. 22.83 per 1000 person-years, log-rank p < 0.001). Multivariable Cox analysis showed that female sex was a poor prognostic factor for the primary endpoint (HR 1.43, 95% CI 1.24–1.64, p < 0.001). This was mainly driven by a higher incidence of new-onset HF admission (HR 1.55, 95% CI 1.34–1.80). However, there was no difference in the incidence of cardiovascular death between the sexes. This result was concordant in the propensity score-matched cohort. In conclusion, women with HCM have worse prognosis, which was mainly driven by a higher new-onset HF admission.Minkwan KimBongsung KimYou-Jung ChoiHyun-Jung LeeHeesun LeeJun-Bean ParkSeung-Pyo LeeKyung-Do HanYong-Jin KimHyung-Kwan KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Minkwan Kim Bongsung Kim You-Jung Choi Hyun-Jung Lee Heesun Lee Jun-Bean Park Seung-Pyo Lee Kyung-Do Han Yong-Jin Kim Hyung-Kwan Kim Sex differences in the prognosis of patients with hypertrophic cardiomyopathy
description	Abstract We investigated sex-related differences in the prognosis of patients with hypertrophic cardiomyopathy (HCM) using the Korea National Health Insurance Service database. From 2010 to 2016, 9524 patients diagnosed with HCM and had more than 1-year follow-up period were analyzed. The primary endpoint was the composite of cardiovascular death or new-onset heart failure (HF) admission. Propensity score-matching analysis was performed to adjust for different baseline characteristics. With a 4.4-years’ median follow-up interval (range 2.0–6.6 years) and male predominance (77.6%), women with HCM were older (52.6 ± 9.7 vs. 51.4 ± 9.1, p < 0.001), had lower incomes, more comorbidities based on Charlson comorbidity index. Women with HCM had a higher incidence of the primary endpoint than men (incidence rate: 34.15 vs. 22.83 per 1000 person-years, log-rank p < 0.001). Multivariable Cox analysis showed that female sex was a poor prognostic factor for the primary endpoint (HR 1.43, 95% CI 1.24–1.64, p < 0.001). This was mainly driven by a higher incidence of new-onset HF admission (HR 1.55, 95% CI 1.34–1.80). However, there was no difference in the incidence of cardiovascular death between the sexes. This result was concordant in the propensity score-matched cohort. In conclusion, women with HCM have worse prognosis, which was mainly driven by a higher new-onset HF admission.
format	article
author	Minkwan Kim Bongsung Kim You-Jung Choi Hyun-Jung Lee Heesun Lee Jun-Bean Park Seung-Pyo Lee Kyung-Do Han Yong-Jin Kim Hyung-Kwan Kim
author_facet	Minkwan Kim Bongsung Kim You-Jung Choi Hyun-Jung Lee Heesun Lee Jun-Bean Park Seung-Pyo Lee Kyung-Do Han Yong-Jin Kim Hyung-Kwan Kim
author_sort	Minkwan Kim
title	Sex differences in the prognosis of patients with hypertrophic cardiomyopathy
title_short	Sex differences in the prognosis of patients with hypertrophic cardiomyopathy
title_full	Sex differences in the prognosis of patients with hypertrophic cardiomyopathy
title_fullStr	Sex differences in the prognosis of patients with hypertrophic cardiomyopathy
title_full_unstemmed	Sex differences in the prognosis of patients with hypertrophic cardiomyopathy
title_sort	sex differences in the prognosis of patients with hypertrophic cardiomyopathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/29293cd5ea3c4f78a2b00543e8be01ed
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Sex differences in the prognosis of patients with hypertrophic cardiomyopathy

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