Effect of Lepidium meyenii (maca) on spatial memory and brain oxidative damage of ovariectomized-rats exposed to mobile phone

Background: Oxidative stress, genetic expression changes, and decomposition of the blood-brain barrier have been shown to be caused by exposure to radiofrequency radiation (RFR); therefore, the search for drugs or food products that offer some protection from these effects has attracted interest. L...

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Autores principales:	Carmen Marín-Tello, Haydée Villafana-Medina, José Aliaga-Arauco, Violeta Malpartida-Tello, Elio Castañeda-Marín, César Sánchez-Marín, Jorge Vásquez-Kool
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2021
Materias:	Ovariectomy Estrogens Nutrition Cognition Malondialdehyde Lepidium meyenii (maca) Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/29294d8ec6654af1a5787359f5fcb8f7
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spelling	oai:doaj.org-article:29294d8ec6654af1a5787359f5fcb8f72021-12-02T19:42:44ZEffect of Lepidium meyenii (maca) on spatial memory and brain oxidative damage of ovariectomized-rats exposed to mobile phone10.17533/udea.vitae.v28n1a3424720121-40042145-2660https://doaj.org/article/29294d8ec6654af1a5787359f5fcb8f72021-01-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/342472https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 Background: Oxidative stress, genetic expression changes, and decomposition of the blood-brain barrier have been shown to be caused by exposure to radiofrequency radiation (RFR); therefore, the search for drugs or food products that offer some protection from these effects has attracted interest. Lepidium meyenii (maca) is a native Andean plant known for its effects on the female reproductive system as well as its immunomodulating, energizing, antioxidant, and nutritive properties due to its high concentration of alkaloids, amino acids, glucosinolates, fatty acids, and macamides. Objectives: We aim to determine the effect of dietary maca supplementation on spatial memory and cerebral oxidative damage in rats with induced menopause and/or with exposure to mobile phone radiation. Method: Female rats divided into 6 groups (six rats in each group): control or not ovariectomized (O-), ovariectomized (O+), ovariectomized + estrogen (O+E+), ovariectomized + estrogen + irradiated (O+E+I+), ovariectomized + maca (O+M+), and ovariectomized + maca + irradiated (O+M+I). Rat spatial memory was tested using the Morris water navigation task. Rats were sacrificed, and cerebral malondialdehyde was measured. Results: After exposure to mobile phone radiation, the group supplemented with maca showed improved spatial memory and lower levels of malondialdehyde than the estrogenized group. Conclusions: Our results suggest that consumption of maca has a positive effect on the maintenance of memory and decreases oxidative stress caused by mobile phone radiation. However, it is necessary to extend this work using a larger sample size. Carmen Marín-TelloHaydée Villafana-MedinaJosé Aliaga-AraucoVioleta Malpartida-TelloElio Castañeda-MarínCésar Sánchez-MarínJorge Vásquez-KoolUniversidad de AntioquiaarticleOvariectomyEstrogensNutritionCognitionMalondialdehydeLepidium meyenii (maca)Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 28, Iss 01 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ovariectomy Estrogens Nutrition Cognition Malondialdehyde Lepidium meyenii (maca) Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Ovariectomy Estrogens Nutrition Cognition Malondialdehyde Lepidium meyenii (maca) Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Carmen Marín-Tello Haydée Villafana-Medina José Aliaga-Arauco Violeta Malpartida-Tello Elio Castañeda-Marín César Sánchez-Marín Jorge Vásquez-Kool Effect of Lepidium meyenii (maca) on spatial memory and brain oxidative damage of ovariectomized-rats exposed to mobile phone
description	Background: Oxidative stress, genetic expression changes, and decomposition of the blood-brain barrier have been shown to be caused by exposure to radiofrequency radiation (RFR); therefore, the search for drugs or food products that offer some protection from these effects has attracted interest. Lepidium meyenii (maca) is a native Andean plant known for its effects on the female reproductive system as well as its immunomodulating, energizing, antioxidant, and nutritive properties due to its high concentration of alkaloids, amino acids, glucosinolates, fatty acids, and macamides. Objectives: We aim to determine the effect of dietary maca supplementation on spatial memory and cerebral oxidative damage in rats with induced menopause and/or with exposure to mobile phone radiation. Method: Female rats divided into 6 groups (six rats in each group): control or not ovariectomized (O-), ovariectomized (O+), ovariectomized + estrogen (O+E+), ovariectomized + estrogen + irradiated (O+E+I+), ovariectomized + maca (O+M+), and ovariectomized + maca + irradiated (O+M+I). Rat spatial memory was tested using the Morris water navigation task. Rats were sacrificed, and cerebral malondialdehyde was measured. Results: After exposure to mobile phone radiation, the group supplemented with maca showed improved spatial memory and lower levels of malondialdehyde than the estrogenized group. Conclusions: Our results suggest that consumption of maca has a positive effect on the maintenance of memory and decreases oxidative stress caused by mobile phone radiation. However, it is necessary to extend this work using a larger sample size.
format	article
author	Carmen Marín-Tello Haydée Villafana-Medina José Aliaga-Arauco Violeta Malpartida-Tello Elio Castañeda-Marín César Sánchez-Marín Jorge Vásquez-Kool
author_facet	Carmen Marín-Tello Haydée Villafana-Medina José Aliaga-Arauco Violeta Malpartida-Tello Elio Castañeda-Marín César Sánchez-Marín Jorge Vásquez-Kool
author_sort	Carmen Marín-Tello
title	Effect of Lepidium meyenii (maca) on spatial memory and brain oxidative damage of ovariectomized-rats exposed to mobile phone
title_short	Effect of Lepidium meyenii (maca) on spatial memory and brain oxidative damage of ovariectomized-rats exposed to mobile phone
title_full	Effect of Lepidium meyenii (maca) on spatial memory and brain oxidative damage of ovariectomized-rats exposed to mobile phone
title_fullStr	Effect of Lepidium meyenii (maca) on spatial memory and brain oxidative damage of ovariectomized-rats exposed to mobile phone
title_full_unstemmed	Effect of Lepidium meyenii (maca) on spatial memory and brain oxidative damage of ovariectomized-rats exposed to mobile phone
title_sort	effect of lepidium meyenii (maca) on spatial memory and brain oxidative damage of ovariectomized-rats exposed to mobile phone
publisher	Universidad de Antioquia
publishDate	2021
url	https://doaj.org/article/29294d8ec6654af1a5787359f5fcb8f7
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Effect of Lepidium meyenii (maca) on spatial memory and brain oxidative damage of ovariectomized-rats exposed to mobile phone

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