FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming

Dendritic cells (DC) are important for maintaining immune homeostasis in the gut, but how they promote intestinal inflammation upon bacterial infection is still unclear. Here the authors show that IgA immune complexes induce proinflammatory cytokine production by metabolic reprogramming of otherwise...

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Autores principales:	Ivo S. Hansen, Lisette Krabbendam, Jochem H. Bernink, Fabricio Loayza-Puch, Willianne Hoepel, Johan A. van Burgsteden, Elsa C. Kuijper, Christianne J. Buskens, Willem A. Bemelman, Sebastiaan A. J. Zaat, Reuven Agami, Gestur Vidarsson, Gijs R. van den Brink, Esther C. de Jong, Manon E. Wildenberg, Dominique L. P. Baeten, Bart Everts, Jeroen den Dunnen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/292a58835f16458d974a1336ef0a74da
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spelling	oai:doaj.org-article:292a58835f16458d974a1336ef0a74da2021-12-02T16:50:11ZFcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming10.1038/s41467-018-03318-52041-1723https://doaj.org/article/292a58835f16458d974a1336ef0a74da2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03318-5https://doaj.org/toc/2041-1723Dendritic cells (DC) are important for maintaining immune homeostasis in the gut, but how they promote intestinal inflammation upon bacterial infection is still unclear. Here the authors show that IgA immune complexes induce proinflammatory cytokine production by metabolic reprogramming of otherwise tolerogenic human CD103+ DCs.Ivo S. HansenLisette KrabbendamJochem H. BerninkFabricio Loayza-PuchWillianne HoepelJohan A. van BurgstedenElsa C. KuijperChristianne J. BuskensWillem A. BemelmanSebastiaan A. J. ZaatReuven AgamiGestur VidarssonGijs R. van den BrinkEsther C. de JongManon E. WildenbergDominique L. P. BaetenBart EvertsJeroen den DunnenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ivo S. Hansen Lisette Krabbendam Jochem H. Bernink Fabricio Loayza-Puch Willianne Hoepel Johan A. van Burgsteden Elsa C. Kuijper Christianne J. Buskens Willem A. Bemelman Sebastiaan A. J. Zaat Reuven Agami Gestur Vidarsson Gijs R. van den Brink Esther C. de Jong Manon E. Wildenberg Dominique L. P. Baeten Bart Everts Jeroen den Dunnen FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming
description	Dendritic cells (DC) are important for maintaining immune homeostasis in the gut, but how they promote intestinal inflammation upon bacterial infection is still unclear. Here the authors show that IgA immune complexes induce proinflammatory cytokine production by metabolic reprogramming of otherwise tolerogenic human CD103+ DCs.
format	article
author	Ivo S. Hansen Lisette Krabbendam Jochem H. Bernink Fabricio Loayza-Puch Willianne Hoepel Johan A. van Burgsteden Elsa C. Kuijper Christianne J. Buskens Willem A. Bemelman Sebastiaan A. J. Zaat Reuven Agami Gestur Vidarsson Gijs R. van den Brink Esther C. de Jong Manon E. Wildenberg Dominique L. P. Baeten Bart Everts Jeroen den Dunnen
author_facet	Ivo S. Hansen Lisette Krabbendam Jochem H. Bernink Fabricio Loayza-Puch Willianne Hoepel Johan A. van Burgsteden Elsa C. Kuijper Christianne J. Buskens Willem A. Bemelman Sebastiaan A. J. Zaat Reuven Agami Gestur Vidarsson Gijs R. van den Brink Esther C. de Jong Manon E. Wildenberg Dominique L. P. Baeten Bart Everts Jeroen den Dunnen
author_sort	Ivo S. Hansen
title	FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming
title_short	FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming
title_full	FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming
title_fullStr	FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming
title_full_unstemmed	FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming
title_sort	fcαri co-stimulation converts human intestinal cd103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/292a58835f16458d974a1336ef0a74da
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FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming

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