Multistep antimicrobial stewardship intervention on antibiotic prescriptions and treatment duration in children with pneumonia.

<h4>Introduction</h4>The Italian antimicrobial prescription rate is one of the highest in Europe, and antibiotic resistance has become a serious problem with high costs and severe consequences, including prolonged illnesses, the increased period of hospitalization and mortality. Inadequa...

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Autores principales:	Sara Rossin, Elisa Barbieri, Anna Cantarutti, Francesco Martinolli, Carlo Giaquinto, Liviana Da Dalt, Daniele Doná
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/292ff7463dae4ffa8ebc035cee5c3d37
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spelling	oai:doaj.org-article:292ff7463dae4ffa8ebc035cee5c3d372021-12-02T20:07:45ZMultistep antimicrobial stewardship intervention on antibiotic prescriptions and treatment duration in children with pneumonia.1932-620310.1371/journal.pone.0257993https://doaj.org/article/292ff7463dae4ffa8ebc035cee5c3d372021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257993https://doaj.org/toc/1932-6203<h4>Introduction</h4>The Italian antimicrobial prescription rate is one of the highest in Europe, and antibiotic resistance has become a serious problem with high costs and severe consequences, including prolonged illnesses, the increased period of hospitalization and mortality. Inadequate antibiotic prescriptions have been frequently reported, especially for lower respiratory tract infections (LRTI); many patients receive antibiotics for viral pneumonia or bronchiolitis or broad-spectrum antibiotics for not complicated community-acquired pneumonia. For this reason, healthcare organizations need to implement strategies to raise physicians' awareness about this kind of drug and their overall effect on the population. The implementation of antibiotic stewardship programs and the use of Clinical Pathways (CPs) are excellent solutions because they have proven to be effective tools at diagnostic and therapeutic levels.<h4>Aims</h4>This study evaluates the impact of CPs implementation in a Pediatric Emergency Department (PED), analyzing antibiotic prescriptions before and after the publication in 2015 and 2019. The CP developed in 2019 represents an update of the previous one with the introduction of serum procalcitonin. The study aims to evaluate the antibiotic prescriptions in patients with community-acquired pneumonia (CAP) before and after both CPs (2015 and 2019).<h4>Methods</h4>The periods analyzed are seven semesters (one before CP-2015 called PRE period, five post CP-2015 called POST 1-5 and 1 post CP-2019 called POST6). The patients have been split into two groups: (i) children admitted to the Pediatric Acute Care Unit (INPATIENTS), and (ii) patients evaluated in the PED and sent back home (OUTPATIENTS). We have analyzed all descriptive diagnosis of CAP (the assessment of episodes with a descriptive diagnosis were conducted independently by two pediatricians) and CAP with ICD9 classification. All antibiotic prescriptions for pediatric patients with CAP were analyzed.<h4>Results</h4>A drastic reduction of broad-spectrum antibiotics prescription for inpatients has been noticed; from 100.0% in the PRE-period to 66.7% in POST1, and up to 38.5% in POST6. Simultaneously, an increase in amoxicillin use from 33.3% in the PRE-period to 76.1% in POST1 (p-value 0.078 and 0.018) has been seen. The outpatients' group's broad-spectrum antibiotics prescriptions decreased from 54.6% PRE to 17.4% in POST6. Both for outpatients and inpatients, there was a decrease of macrolides. The inpatient group's antibiotic therapy duration decreased from 13.5 days (PRE-period) to 7.0 days in the POST6. Antibiotic therapy duration in the outpatient group decreased from 9.0 days (PRE) to 7.0 days (POST1), maintaining the same value in subsequent periods. Overlapping results were seen in the ICD9 group for both inpatients and outpatients.<h4>Conclusions</h4>This study shows that CPs are effective tools for an antibiotic stewardship program. Indeed, broad-spectrum antibiotics usage has dropped and amoxicillin prescriptions have increased after implementing the CAP CP-2015 and the 2019 update.Sara RossinElisa BarbieriAnna CantaruttiFrancesco MartinolliCarlo GiaquintoLiviana Da DaltDaniele DonáPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0257993 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sara Rossin Elisa Barbieri Anna Cantarutti Francesco Martinolli Carlo Giaquinto Liviana Da Dalt Daniele Doná Multistep antimicrobial stewardship intervention on antibiotic prescriptions and treatment duration in children with pneumonia.
description	<h4>Introduction</h4>The Italian antimicrobial prescription rate is one of the highest in Europe, and antibiotic resistance has become a serious problem with high costs and severe consequences, including prolonged illnesses, the increased period of hospitalization and mortality. Inadequate antibiotic prescriptions have been frequently reported, especially for lower respiratory tract infections (LRTI); many patients receive antibiotics for viral pneumonia or bronchiolitis or broad-spectrum antibiotics for not complicated community-acquired pneumonia. For this reason, healthcare organizations need to implement strategies to raise physicians' awareness about this kind of drug and their overall effect on the population. The implementation of antibiotic stewardship programs and the use of Clinical Pathways (CPs) are excellent solutions because they have proven to be effective tools at diagnostic and therapeutic levels.<h4>Aims</h4>This study evaluates the impact of CPs implementation in a Pediatric Emergency Department (PED), analyzing antibiotic prescriptions before and after the publication in 2015 and 2019. The CP developed in 2019 represents an update of the previous one with the introduction of serum procalcitonin. The study aims to evaluate the antibiotic prescriptions in patients with community-acquired pneumonia (CAP) before and after both CPs (2015 and 2019).<h4>Methods</h4>The periods analyzed are seven semesters (one before CP-2015 called PRE period, five post CP-2015 called POST 1-5 and 1 post CP-2019 called POST6). The patients have been split into two groups: (i) children admitted to the Pediatric Acute Care Unit (INPATIENTS), and (ii) patients evaluated in the PED and sent back home (OUTPATIENTS). We have analyzed all descriptive diagnosis of CAP (the assessment of episodes with a descriptive diagnosis were conducted independently by two pediatricians) and CAP with ICD9 classification. All antibiotic prescriptions for pediatric patients with CAP were analyzed.<h4>Results</h4>A drastic reduction of broad-spectrum antibiotics prescription for inpatients has been noticed; from 100.0% in the PRE-period to 66.7% in POST1, and up to 38.5% in POST6. Simultaneously, an increase in amoxicillin use from 33.3% in the PRE-period to 76.1% in POST1 (p-value 0.078 and 0.018) has been seen. The outpatients' group's broad-spectrum antibiotics prescriptions decreased from 54.6% PRE to 17.4% in POST6. Both for outpatients and inpatients, there was a decrease of macrolides. The inpatient group's antibiotic therapy duration decreased from 13.5 days (PRE-period) to 7.0 days in the POST6. Antibiotic therapy duration in the outpatient group decreased from 9.0 days (PRE) to 7.0 days (POST1), maintaining the same value in subsequent periods. Overlapping results were seen in the ICD9 group for both inpatients and outpatients.<h4>Conclusions</h4>This study shows that CPs are effective tools for an antibiotic stewardship program. Indeed, broad-spectrum antibiotics usage has dropped and amoxicillin prescriptions have increased after implementing the CAP CP-2015 and the 2019 update.
format	article
author	Sara Rossin Elisa Barbieri Anna Cantarutti Francesco Martinolli Carlo Giaquinto Liviana Da Dalt Daniele Doná
author_facet	Sara Rossin Elisa Barbieri Anna Cantarutti Francesco Martinolli Carlo Giaquinto Liviana Da Dalt Daniele Doná
author_sort	Sara Rossin
title	Multistep antimicrobial stewardship intervention on antibiotic prescriptions and treatment duration in children with pneumonia.
title_short	Multistep antimicrobial stewardship intervention on antibiotic prescriptions and treatment duration in children with pneumonia.
title_full	Multistep antimicrobial stewardship intervention on antibiotic prescriptions and treatment duration in children with pneumonia.
title_fullStr	Multistep antimicrobial stewardship intervention on antibiotic prescriptions and treatment duration in children with pneumonia.
title_full_unstemmed	Multistep antimicrobial stewardship intervention on antibiotic prescriptions and treatment duration in children with pneumonia.
title_sort	multistep antimicrobial stewardship intervention on antibiotic prescriptions and treatment duration in children with pneumonia.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/292ff7463dae4ffa8ebc035cee5c3d37
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Multistep antimicrobial stewardship intervention on antibiotic prescriptions and treatment duration in children with pneumonia.

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