High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli.

<h4>Background</h4>Artemisinin derivatives are the key active ingredients in Artemisinin combination therapies (ACTs), the most effective therapies available for treatment of malaria. Because the raw material is extracted from plants with long growing seasons, artemisinin is often in sho...

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Autores principales: Hiroko Tsuruta, Christopher J Paddon, Diana Eng, Jacob R Lenihan, Tizita Horning, Larry C Anthony, Rika Regentin, Jay D Keasling, Neil S Renninger, Jack D Newman
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
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Acceso en línea:https://doaj.org/article/29329a6165654224a54f2846107a793c
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