Investigation of triple-negative breast cancer risk alleles in an International African-enriched cohort

Investigation of triple-negative breast cancer risk alleles in an International African-enriched cohort

Abstract Large-scale efforts to identify breast cancer (BC) risk alleles have historically taken place among women of European ancestry. Recently, there are new efforts to verify if these alleles increase risk in African American (AA) women as well. We investigated the effect of previously reported...

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Autores principales: Rachel Martini, Yalei Chen, Brittany D. Jenkins, Isra A. Elhussin, Esther Cheng, Syed A. Hoda, Paula S. Ginter, Jeffrey Hanover, Rozina B. Zeidan, Joseph K. Oppong, Ernest K. Adjei, Aisha Jibril, Dhananjay Chitale, Jessica M. Bensenhaver, Baffour Awuah, Mahteme Bekele, Engida Abebe, Ishmael Kyei, Frances S. Aitpillah, Michael O. Adinku, Kwasi Ankomah, Ernest B. Osei-Bonsu, Saul David Nathansan, LaToya Jackson, Evelyn Jiagge, Lindsay F. Petersen, Erica Proctor, Petros Nikolinakos, Kofi K. Gyan, Clayton Yates, Rick Kittles, Lisa A. Newman, Melissa B. Davis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/293723ba5c174d8fa209051f5c7c3e6a
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spelling oai:doaj.org-article:293723ba5c174d8fa209051f5c7c3e6a2021-12-02T16:55:46ZInvestigation of triple-negative breast cancer risk alleles in an International African-enriched cohort10.1038/s41598-021-88613-w2045-2322https://doaj.org/article/293723ba5c174d8fa209051f5c7c3e6a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88613-whttps://doaj.org/toc/2045-2322Abstract Large-scale efforts to identify breast cancer (BC) risk alleles have historically taken place among women of European ancestry. Recently, there are new efforts to verify if these alleles increase risk in African American (AA) women as well. We investigated the effect of previously reported AA breast cancer and triple-negative breast cancer (TNBC) risk alleles in our African-enriched International Center for the Study of Breast Cancer Subtypes (ICSBCS) cohort. Using case–control, case-series and race-nested approaches, we report that the Duffy-null allele (rs2814778) is associated with TNBC risk (OR = 3.814, p = 0.001), specifically among AA individuals, after adjusting for self-indicated race and west African ancestry (OR = 3.368, p = 0.007). We have also validated the protective effect of the minor allele of the ANKLE1 missense variant rs2363956 among AA for TNBC (OR = 0.420, p = 0.005). Our results suggest that an ancestry-specific Duffy-null allele and differential prevalence of a polymorphic gene variant of ANKLE1 may play a role in TNBC breast cancer outcomes. These findings present opportunities for therapeutic potential and future studies to address race-specific differences in TNBC risk and disease outcome.Rachel MartiniYalei ChenBrittany D. JenkinsIsra A. ElhussinEsther ChengSyed A. HodaPaula S. GinterJeffrey HanoverRozina B. ZeidanJoseph K. OppongErnest K. AdjeiAisha JibrilDhananjay ChitaleJessica M. BensenhaverBaffour AwuahMahteme BekeleEngida AbebeIshmael KyeiFrances S. AitpillahMichael O. AdinkuKwasi AnkomahErnest B. Osei-BonsuSaul David NathansanLaToya JacksonEvelyn JiaggeLindsay F. PetersenErica ProctorPetros NikolinakosKofi K. GyanClayton YatesRick KittlesLisa A. NewmanMelissa B. DavisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Rachel Martini
Yalei Chen
Brittany D. Jenkins
Isra A. Elhussin
Esther Cheng
Syed A. Hoda
Paula S. Ginter
Jeffrey Hanover
Rozina B. Zeidan
Joseph K. Oppong
Ernest K. Adjei
Aisha Jibril
Dhananjay Chitale
Jessica M. Bensenhaver
Baffour Awuah
Mahteme Bekele
Engida Abebe
Ishmael Kyei
Frances S. Aitpillah
Michael O. Adinku
Kwasi Ankomah
Ernest B. Osei-Bonsu
Saul David Nathansan
LaToya Jackson
Evelyn Jiagge
Lindsay F. Petersen
Erica Proctor
Petros Nikolinakos
Kofi K. Gyan
Clayton Yates
Rick Kittles
Lisa A. Newman
Melissa B. Davis
Investigation of triple-negative breast cancer risk alleles in an International African-enriched cohort
description Abstract Large-scale efforts to identify breast cancer (BC) risk alleles have historically taken place among women of European ancestry. Recently, there are new efforts to verify if these alleles increase risk in African American (AA) women as well. We investigated the effect of previously reported AA breast cancer and triple-negative breast cancer (TNBC) risk alleles in our African-enriched International Center for the Study of Breast Cancer Subtypes (ICSBCS) cohort. Using case–control, case-series and race-nested approaches, we report that the Duffy-null allele (rs2814778) is associated with TNBC risk (OR = 3.814, p = 0.001), specifically among AA individuals, after adjusting for self-indicated race and west African ancestry (OR = 3.368, p = 0.007). We have also validated the protective effect of the minor allele of the ANKLE1 missense variant rs2363956 among AA for TNBC (OR = 0.420, p = 0.005). Our results suggest that an ancestry-specific Duffy-null allele and differential prevalence of a polymorphic gene variant of ANKLE1 may play a role in TNBC breast cancer outcomes. These findings present opportunities for therapeutic potential and future studies to address race-specific differences in TNBC risk and disease outcome.
format article
author Rachel Martini
Yalei Chen
Brittany D. Jenkins
Isra A. Elhussin
Esther Cheng
Syed A. Hoda
Paula S. Ginter
Jeffrey Hanover
Rozina B. Zeidan
Joseph K. Oppong
Ernest K. Adjei
Aisha Jibril
Dhananjay Chitale
Jessica M. Bensenhaver
Baffour Awuah
Mahteme Bekele
Engida Abebe
Ishmael Kyei
Frances S. Aitpillah
Michael O. Adinku
Kwasi Ankomah
Ernest B. Osei-Bonsu
Saul David Nathansan
LaToya Jackson
Evelyn Jiagge
Lindsay F. Petersen
Erica Proctor
Petros Nikolinakos
Kofi K. Gyan
Clayton Yates
Rick Kittles
Lisa A. Newman
Melissa B. Davis
author_facet Rachel Martini
Yalei Chen
Brittany D. Jenkins
Isra A. Elhussin
Esther Cheng
Syed A. Hoda
Paula S. Ginter
Jeffrey Hanover
Rozina B. Zeidan
Joseph K. Oppong
Ernest K. Adjei
Aisha Jibril
Dhananjay Chitale
Jessica M. Bensenhaver
Baffour Awuah
Mahteme Bekele
Engida Abebe
Ishmael Kyei
Frances S. Aitpillah
Michael O. Adinku
Kwasi Ankomah
Ernest B. Osei-Bonsu
Saul David Nathansan
LaToya Jackson
Evelyn Jiagge
Lindsay F. Petersen
Erica Proctor
Petros Nikolinakos
Kofi K. Gyan
Clayton Yates
Rick Kittles
Lisa A. Newman
Melissa B. Davis
author_sort Rachel Martini
title Investigation of triple-negative breast cancer risk alleles in an International African-enriched cohort
title_short Investigation of triple-negative breast cancer risk alleles in an International African-enriched cohort
title_full Investigation of triple-negative breast cancer risk alleles in an International African-enriched cohort
title_fullStr Investigation of triple-negative breast cancer risk alleles in an International African-enriched cohort
title_full_unstemmed Investigation of triple-negative breast cancer risk alleles in an International African-enriched cohort
title_sort investigation of triple-negative breast cancer risk alleles in an international african-enriched cohort
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/293723ba5c174d8fa209051f5c7c3e6a
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