A glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation

Herpesvirus virions have an outer lipid membrane dotted with glycoproteins that enable fusion with cell membranes to initiate entry and establish infection. Here the authors elucidate the structural mechanism of a neutralizing antibody derived from a patient infected by the herpesvirus varicella-zos...

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Autores principales:	Stefan L. Oliver, Yi Xing, Dong-Hua Chen, Soung Hun Roh, Grigore D. Pintilie, David A. Bushnell, Marvin H. Sommer, Edward Yang, Andrea Carfi, Wah Chiu, Ann M. Arvin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/29372bf848da493084861c63723dc16f
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spelling	oai:doaj.org-article:29372bf848da493084861c63723dc16f2021-12-02T16:46:37ZA glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation10.1038/s41467-020-17911-02041-1723https://doaj.org/article/29372bf848da493084861c63723dc16f2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17911-0https://doaj.org/toc/2041-1723Herpesvirus virions have an outer lipid membrane dotted with glycoproteins that enable fusion with cell membranes to initiate entry and establish infection. Here the authors elucidate the structural mechanism of a neutralizing antibody derived from a patient infected by the herpesvirus varicella-zoster virus and targeted to its fusogen, glycoprotein-B.Stefan L. OliverYi XingDong-Hua ChenSoung Hun RohGrigore D. PintilieDavid A. BushnellMarvin H. SommerEdward YangAndrea CarfiWah ChiuAnn M. ArvinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stefan L. Oliver Yi Xing Dong-Hua Chen Soung Hun Roh Grigore D. Pintilie David A. Bushnell Marvin H. Sommer Edward Yang Andrea Carfi Wah Chiu Ann M. Arvin A glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation
description	Herpesvirus virions have an outer lipid membrane dotted with glycoproteins that enable fusion with cell membranes to initiate entry and establish infection. Here the authors elucidate the structural mechanism of a neutralizing antibody derived from a patient infected by the herpesvirus varicella-zoster virus and targeted to its fusogen, glycoprotein-B.
format	article
author	Stefan L. Oliver Yi Xing Dong-Hua Chen Soung Hun Roh Grigore D. Pintilie David A. Bushnell Marvin H. Sommer Edward Yang Andrea Carfi Wah Chiu Ann M. Arvin
author_facet	Stefan L. Oliver Yi Xing Dong-Hua Chen Soung Hun Roh Grigore D. Pintilie David A. Bushnell Marvin H. Sommer Edward Yang Andrea Carfi Wah Chiu Ann M. Arvin
author_sort	Stefan L. Oliver
title	A glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation
title_short	A glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation
title_full	A glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation
title_fullStr	A glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation
title_full_unstemmed	A glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation
title_sort	glycoprotein b-neutralizing antibody structure at 2.8 å uncovers a critical domain for herpesvirus fusion initiation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/29372bf848da493084861c63723dc16f
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A glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation

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